hemophagocytic_lymphohistiocytosis-Vaxxed_TruthForHealth_VaccineInjuryResources
Vaccine

Hemophagocytic lymphohistiocytosis after COVID-19 vaccination

Abstract

Cases of thrombotic thrombocytopenia induced by coronavirus disease 2019 (COVID-19) vaccines have been reported recently. Herein, we describe the first case of another critical disorder, hemophagocytic lymphohistiocytosis (HLH), in a healthy individual after COVID-19 vaccination. A 43-year-old Chinese farmer developed malaise, vomiting, and persistent high fever (up to 39.7 °C) shortly after receiving the first dose of the inactivated SARS-CoV-2 vaccine. The initial evaluation showed pancytopenia (neutrophil count, 0.70 × 109/L; hemoglobin, 113 g/L; platelet, 27 × 109/L), elevated triglyceride (2.43 mmol/L), and decreased fibrinogen (1.41 g/L). Further tests showed high serum ferritin levels (8140.4 μg/L), low NK cell cytotoxicity (50.13%-60.83%), and positive tests for Epstein-Barr virus (EBV) DNA. Hemophagocytosis was observed in the bone marrow. Therefore, HLH was confirmed, and dexamethasone acetate (10 mg/day) was immediately prescribed without etoposide. Signs and abnormal laboratory results resolved gradually, and the patient was discharged. HLH is a life-threatening hyperinflammatory syndrome caused by aberrantly activated macrophages and cytotoxic T cells, which may rapidly progress to terminal multiple organ failure. In this case, HLH was induced by the COVID-19 vaccination immuno-stimulation on a chronic EBV infection background. This report indicates that it is crucial to exclude the presence of active EBV infection or other common viruses before COVID-19 vaccination.

Keywords: COVID-19; Coagulopathy; Epstein–Barr virus; Hemophagocytic lymphohistiocytosis; SARS-CoV-2 vaccine.

DOWNLOAD

You may also like...

Popular Articles...

5 Comments

  1. … [Trackback]

    […] Read More here to that Topic: truthforhealth.org/2022/04/hemophagocytic-lymphohistiocytosis-after-covid-19-vaccination/ […]

  2. … [Trackback]

    […] Find More on on that Topic: truthforhealth.org/2022/04/hemophagocytic-lymphohistiocytosis-after-covid-19-vaccination/ […]

  3. … [Trackback]

    […] Read More to that Topic: truthforhealth.org/2022/04/hemophagocytic-lymphohistiocytosis-after-covid-19-vaccination/ […]

  4. … [Trackback]

    […] Find More Info here to that Topic: truthforhealth.org/2022/04/hemophagocytic-lymphohistiocytosis-after-covid-19-vaccination/ […]

  5. … [Trackback]

    […] Find More on that Topic: truthforhealth.org/2022/04/hemophagocytic-lymphohistiocytosis-after-covid-19-vaccination/ […]

Leave a Reply