{"id":5743,"date":"2023-03-02T02:37:17","date_gmt":"2023-03-02T02:37:17","guid":{"rendered":"https:\/\/www.truthforhealth.org\/?p=5743"},"modified":"2023-11-04T15:40:09","modified_gmt":"2023-11-04T15:40:09","slug":"antibody-dependent-enhancement-andsars-cov-2-vaccines-and-therapies","status":"publish","type":"post","link":"https:\/\/www.truthforhealth.org\/es\/2023\/03\/antibody-dependent-enhancement-andsars-cov-2-vaccines-and-therapies\/","title":{"rendered":"Antibody-dependent enhancement and SARS-CoV-2 vaccines and therapies"},"content":{"rendered":"<p class=\"wp-block-paragraph\">Antibody-based drugs and vaccines against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) are being expedited through preclinical and clinical development. Data from the study of SARS-CoV and other respiratory viruses suggest that<br>anti-SARS-CoV-2 antibodies could exacerbate COVID-19 through antibody-dependent enhancement (ADE). Previous respiratory syncytial virus and dengue virus vaccine studies revealed human clinical safety risks related to ADE, resulting in failed vaccine trials. Here, we describe key ADE mechanisms and discuss mitigation strategies for SARS-CoV-2 vaccines and therapies<br>in development. We also outline recently published data to evaluate the risks and opportunities for antibody-based protection<br>against SARS-CoV-2.<\/p>\n\n\n<div class=\"embed-pdf-viewer-wrapper aligncenter wp-block-embed-pdf-viewer-pdf\"><iframe loading=\"lazy\" class=\"embed-pdf-viewer\" src=\"https:\/\/www.truthforhealth.org\/wp-content\/uploads\/2023\/03\/s41564-020-00789-5.pdf\" height=\"600\" width=\"600\" title=\"\"><\/iframe><\/div>","protected":false},"excerpt":{"rendered":"<p>Antibody-based drugs and vaccines against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) are being expedited through preclinical and clinical development. Data from the study of SARS-CoV and other respiratory viruses &hellip; <\/p>","protected":false},"author":3,"featured_media":5745,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":""},"categories":[167,106,25],"tags":[],"class_list":["post-5743","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-vaccine","category-vaccine-injury","category-vaccine-news-news","fadeIn","image-hover-transition-effect","latest_post"],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v28.5 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>Antibody-dependent enhancement and SARS-CoV-2 vaccines and therapies - Truth for Health Foundation<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.truthforhealth.org\/es\/2023\/03\/antibody-dependent-enhancement-andsars-cov-2-vaccines-and-therapies\/\" \/>\n<meta property=\"og:locale\" content=\"es_MX\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Antibody-dependent enhancement and SARS-CoV-2 vaccines and therapies - Truth for Health Foundation\" \/>\n<meta property=\"og:description\" content=\"Antibody-based drugs and vaccines against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) are being expedited through preclinical and clinical development. 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