{"id":3300,"date":"2022-04-23T00:33:34","date_gmt":"2022-04-23T00:33:34","guid":{"rendered":"https:\/\/www.truthforhealth.org\/?p=3300"},"modified":"2022-04-23T00:33:37","modified_gmt":"2022-04-23T00:33:37","slug":"pathogenic-priming-likely-contributes-to-serious-and-critical-illness-and-mortality-in-covid-19-via-autoimmunity","status":"publish","type":"post","link":"https:\/\/www.truthforhealth.org\/es\/2022\/04\/pathogenic-priming-likely-contributes-to-serious-and-critical-illness-and-mortality-in-covid-19-via-autoimmunity\/","title":{"rendered":"Pathogenic priming likely contributes to serious and critical illness and mortality in COVID-19 via autoimmunity"},"content":{"rendered":"<p class=\"wp-block-paragraph\"><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/?term=Lyons-Weiler+J&amp;cauthor_id=32292901\">James Lyons-Weiler<\/a><sup>&nbsp;<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/32292901\/#affiliation-1\">1<\/a><\/sup>Affiliations&nbsp;expand<\/p>\n\n\n\n<ul class=\"wp-block-list\" id=\"full-view-identifiers\"><li>PMID:&nbsp;<strong>32292901<\/strong><\/li><li>PMCID:&nbsp;<a target=\"_blank\" rel=\"noreferrer noopener\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/pmc7142689\/\">PMC7142689<\/a><\/li><li>DOI:&nbsp;<a target=\"_blank\" rel=\"noreferrer noopener\" href=\"https:\/\/doi.org\/10.1016\/j.jtauto.2020.100051\">10.1016\/j.jtauto.2020.100051<\/a><\/li><\/ul>\n\n\n\n<p class=\"wp-block-paragraph\">Free PMC article<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Abstract<\/h2>\n\n\n\n<p class=\"wp-block-paragraph\">Homology between human and viral proteins is an established factor in viral- or vaccine-induced autoimmunity. Failure of SARS and MERS vaccines in animal trials involved pathogenesis consistent with an immunological priming that could involve autoimmunity in lung tissues due to previous exposure to the SARS and MERS spike protein. Exposure pathogenesis to SARS-CoV-2 in COVID-19 likely will lead to similar outcomes. Immunogenic peptides in viruses or bacteria that match human proteins are good candidates for pathogenic priming peptides (similar to the more diffuse idea of &#8220;immune enhancement&#8221;). Here I provide an assessment of potential for human pathogenesis via autoimmunity via exposure, via infection or injection. SAR-CoV-2 spike proteins, and all other SARS-CoV-2 proteins, immunogenic epitopes in each SARS-CoV-2 protein were compared to human proteins in search of high local homologous matching. Only one immunogenic epitope in a SARS-CoV-2 had no homology to human proteins. If all of the parts of the epitopes that are homologous to human proteins are excluded from consideration due to risk of pathogenic priming, the remaining immunogenic parts of the epitopes may be still immunogenic and remain as potentially viable candidates for vaccine development. Mapping of the genes encoding human protein matches to pathways point to targets that could explain the observed presentation of symptoms in COVID-19 disease. It also strongly points to a large number of opportunities for expected disturbances in the immune system itself, targeting elements of MHC Class I and Class II antigen presentation, PD-1 signaling, cross-presentation of soluble exogenous antigens and the ER-Phagosome pathway. Translational consequences of these findings are explored.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>Keywords:&nbsp;<\/strong>Autoimmunity; COVID-19; Immune Enhancement; Pathogenic priming; SARS-CoV-2.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\" id=\"copyright\">\u00a9 2020 The Author(s).<\/p>\n\n\n\n<h3 class=\"wp-block-heading\">Conflict of interest statement<\/h3>\n\n\n\n<p class=\"wp-block-paragraph\">Dr. Lyons-Weiler has, in the past, served as expert witness in the National Vaccine Injury Compensation Program.<\/p>\n\n\n\n<p class=\"has-medium-font-size wp-block-paragraph\"><strong><a href=\"http:\/\/www.truthforhealth.org\/wp-content\/uploads\/2022\/04\/Pathogenic-priming-likely-contributes-to-serious-and-critical-illness.pdf\" target=\"_blank\" rel=\"noreferrer noopener\">Download Document (Click Here)<\/a><\/strong><\/p>","protected":false},"excerpt":{"rendered":"<p>James Lyons-Weiler&nbsp;1Affiliations&nbsp;expand PMID:&nbsp;32292901 PMCID:&nbsp;PMC7142689 DOI:&nbsp;10.1016\/j.jtauto.2020.100051 Free PMC article Abstract Homology between human and viral proteins is an established factor in viral- or vaccine-induced autoimmunity. Failure of SARS and MERS vaccines &hellip; <\/p>","protected":false},"author":3,"featured_media":3302,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":""},"categories":[167],"tags":[],"class_list":["post-3300","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-vaccine","fadeIn","image-hover-transition-effect","latest_post"],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v28.5 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>Pathogenic priming likely contributes to serious and critical illness and mortality in COVID-19 via autoimmunity - Truth for Health Foundation<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.truthforhealth.org\/es\/2022\/04\/pathogenic-priming-likely-contributes-to-serious-and-critical-illness-and-mortality-in-covid-19-via-autoimmunity\/\" \/>\n<meta property=\"og:locale\" content=\"es_MX\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Pathogenic priming likely contributes to serious and critical illness and mortality in COVID-19 via autoimmunity - Truth for Health Foundation\" \/>\n<meta property=\"og:description\" content=\"James Lyons-Weiler&nbsp;1Affiliations&nbsp;expand PMID:&nbsp;32292901 PMCID:&nbsp;PMC7142689 DOI:&nbsp;10.1016\/j.jtauto.2020.100051 Free PMC article Abstract Homology between human and viral proteins is an established factor in viral- or vaccine-induced autoimmunity. 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