{"id":11016,"date":"2026-10-29T15:23:11","date_gmt":"2026-10-29T15:23:11","guid":{"rendered":"https:\/\/www.truthforhealth.org\/?p=11016"},"modified":"2026-10-29T15:23:11","modified_gmt":"2026-10-29T15:23:11","slug":"dr-vliets-health-tip-estradiol-testosterone-and-painful-joints-connecting-the-dots","status":"publish","type":"post","link":"https:\/\/www.truthforhealth.org\/es\/2026\/10\/dr-vliets-health-tip-estradiol-testosterone-and-painful-joints-connecting-the-dots\/","title":{"rendered":"Dr. Vliet\u2019s Health Tip: Estradiol, Testosterone and Painful Joints\u2014Connecting the Dots"},"content":{"rendered":"<h3 class=\"null\"><strong>The Hormone &#8211; Joint Pain Connection for Men and Women<\/strong><\/h3>\n<p>Joint pain is commonly written off by most doctors as just \u201carthritis\u201d because you are getting older.\u00a0 But the truth is far more complex than just getting older, or the usual \u201cwear and tear\u201d explanation.\u00a0 Likewise, there are many more helpful, integrative and comprehensive approaches to joint pain relief than just taking Tylenol, Aleve, Advil, or aspirin. As I said in last week\u2019s Health Tip, joint pain does not always begin with an injury or joints getting \u201cworn-out\u201d as we get older.\u00a0 More often than people realize, before the pain, there was a change in the hormonal balance\u2014particularly with our sex hormones\u2014that is a critical factor explaining why familiar activities suddenly hurt, morning stiffness lasts longer, or several joints become uncomfortable at once.<\/p>\n<p>I want to help you avoid the pitfall of simply dismissing new pain as a sign of age and accepting that all you can do is take pain medicine.\u00a0 The truth rarely discussed in most doctors\u2019 offices is that there are many different contributors to joint pain, from leptin signaling in overweight individuals to declining estrogen and testosterone during menopause and andropause to other medical conditions and medications that dramatically drop or completely block hormone receptors leading to painful joints and other life-altering symptoms.<\/p>\n<p>So, today\u2019s Health Tip expands on last week\u2019s article on the overlooked connection between leptin and joint pain as I discuss this even bigger and tragically overlooked connection contributing to painful joints \u2013 decline or imbalance in your sex hormones: estradiol and testosterone women, testosterone and estradiol for men. Yes, women have testosterone and men have estradiol although the healthy, optimal balances vary based on biological sex chromosomes (XX or XY) present.<\/p>\n<p>Our sex hormones have many roles in the health of our joints and the connective tissues and muscles that stabilize and help the joints work normally and without pain<em>: lubrication, blood flow, healthy joint lining, nerve function, strength and flexibility of tendons and ligaments, reducing inflammation from daily use, improving repair processes from microtraumas each day, wound healing after injury, coordination, balance and proprioception.<\/em><\/p>\n<p>Our sex hormones\u00a0 play key roles in ALL these functions!\u00a0 It is a lot \u2013 and most doctors never even mention it when patients come in describing painful joints, loss of mobility and strength.\u00a0 I\u2019ll talk about these functions in more detail today \u2013and give you some practical Tips to help with creative approaches to treatment.<\/p>\n<h3>Understanding Joint Function and Health: More than \u201cwear and tear\u201d: what actually hurts?<\/h3>\n<p>A joint functions as a system. Cartilage covers the ends of bones; the synovium, or joint lining, helps maintain the joint environment; tendons connect muscles to bones; and ligaments provide stability. Muscles control movement and help the body tolerate load.<\/p>\n<p>I listed above the many ways our sex hormones affect multiple aspects of\u00a0 this carefully designed integrated system. Sex hormones also change how readily sensory nerves respond to inflammatory signals and how strongly the spinal cord and brain amplify those signals. Consequently, hormonal imbalance (estradiol deficit, progesterone excess, testosterone excess or deficit, DHEA excess), can result in significant increase in pain even without an equivalent increase in structural damage.<\/p>\n<p>This distinction is fundamental: pain and joint deterioration are related, but they are not interchangeable. A person may experience significant relief because inflammation, tendon irritation, or nerve sensitivity improves\u2014not because cartilage has regenerated.<\/p>\n<h3>Estrogen and Testosterone role in Joint Pain<\/h3>\n<p>Both hormones clearly influence multiple functions that affect the strength and integrity of the tissues that surround and support joints, the signals that regulate inflammation, and the nervous system\u2019s response to pain. Both women and men produce both hormones, but the balance of E2 and testosterone in men and women obviously differ.<\/p>\n<ul>\n<li>\n<h3>Testosterone: muscle support, bone health, &amp; pain modulation<\/h3>\n<\/li>\n<\/ul>\n<p>Testosterone is present in both sexes in different amounts, and also shares similar functions for men and women to maintain health of connective tissue, muscle, bone and joint health.\u00a0 Hypogonadism is the medical term for clinically significant testosterone deficiency in men, regardless of age or cause (medical conditions, medications, trauma, cancer, alcohol or drug use, etc). Menopause is the general medical term used to describe the loss of ovarian hormones in women.\u00a0 In natural menopause, estradiol declines more rapidly, while ovarian testosterone declines more gradually.\u00a0 Adrenal glands continue to make adrenal androgens (DHEA and DHEA-S, small amounts of testosterone) in women after menopause, but without functioning ovaries, precursor DHEA cannot be converted to the end hormones of estradiol and testosterone.\u00a0 Taking DHEA supplements in post-menopausal women just adds unwanted symptoms of androgen excess but without estradiol or the right amount of testosterone to balance it.\u00a0 After hysterectomy with removal of both ovaries, or surgical menopause, women immediately and abruptly lose both estradiol and ovarian androgens (testosterone, DHEA and DHEA-S).\u00a0 Removal of the ovaries in women is the same catastrophic loss of hormones as castration by removal of testes in men.<\/p>\n<p>Whether for men or women, loss of testosterone gradually leads to reduced muscle mass, loss of bone mass, loss of strong connective tissue around joints, and decline in physical stamina and strength.\u00a0 Together, these changes make everyday activity more difficult and more painful because testosterone also interacts with pain-processing pathways and plays a role in deep restorative sleep for men that helps repair muscle and connective tissue from the microtraumas that occur over a day of activity. Estradiol plays a similar and crucial role in maintaining the normal, restorative sleep pathway in women.<\/p>\n<ul>\n<li>\n<h3>Estradiol: Critical for joint, bone and muscle health in both men and women<\/h3>\n<\/li>\n<\/ul>\n<p>Estradiol (E2), or 17-besta estradiol, is the primary, metabolically active form of estrogen prior to menopause, and it is present in women but also in smaller amounts in men. Estradiol shares similar functions on bone, connective tissue, nerves, brain and other organs in both sexes.<\/p>\n<p>Men produce estradiol largely by converting testosterone through an enzyme called aromatase. In men, estradiol plays an important role in maintaining bone; treatments that lower testosterone can also lower estradiol leading to bone loss in men. \u00a0In fact, studies in the bone and mineral research field from 30 years ago found that both men and women need a critical blood level of 17-beta estradiol of about 60 pg\/ml to maintain normal bone preservation pathways.<\/p>\n<p>It is critical to understand this connection between the hormones and joint health vs. deterioration and pain because the roles these hormones play opens the door to therapeutic options for better pain management. I am not saying that every painful joint reflects a hormone deficiency, or that hormone replacement by itself rebuilds damaged or missing cartilage. I do know from 40+ years of practice in this field of reproductive hormones effects on our total health that effective treatment for painful joints must start with assessing the current state of hormone balance, along with the other medical and nutritional factors I assess in all my new patients. It is part of my careful evaluation to determine the root causes and apply appropriate integrated medical-endocrine-nutritional and lifestyle strategies that I tailor to each person\u2019s treatment plans.<\/p>\n<ul>\n<li>\n<h3>Estradiol influences connective tissue<\/h3>\n<\/li>\n<\/ul>\n<p>Estradiol signaling affects collagen formation\u2014the structural protein that gives tendons, ligaments, and other connective tissues their mechanical properties. It influences collagen production, increases collagen content of connective tissue, increases collage cross-linking and elasticity, which help determine how tendons and ligaments respond to stretching and loading. In muscle and bone, estradiol primarily improves strength and function. In tendons and ligaments, estradiol decreases stiffness, and increases elasticity, which directly affects <a href=\"https:\/\/pmc.ncbi.nlm.nih.gov\/articles\/PMC6341375\/\" data-saferedirecturl=\"https:\/\/www.google.com\/url?q=https:\/\/pmc.ncbi.nlm.nih.gov\/articles\/PMC6341375\/&amp;source=gmail&amp;ust=1792965198585000&amp;usg=AOvVaw19vvUfDAm6awbZ51tp4okd\">performance and injury rates<\/a>.<\/p>\n<ul>\n<li>\n<h3>Estradiol influences inflammation and pain processing<\/h3>\n<\/li>\n<\/ul>\n<p>Estradiol receptors act as cellular signal receivers. They are present in tissues and neural pathways involved in pain. Estradiol can modify inflammatory gene activity, sensory-neuron excitability, and signaling in the spinal cord and brain.\u00a0 This means that depending on the tissue, estradiol may have differing effects\u2014reducing pain sensitivity in some, and in others, facilitating pain transmission. The response depends on receptor type, tissue, hormonal context, and the underlying pain disorder. <strong>Estradiol is a regulator of pain pathways in ways that modulates and can reduce pain and is important in pain management, but it is not a \u201cpainkiller\u201d like NSAIDS or opiates.<\/strong><\/p>\n<ul>\n<li>\n<h3>Estradiol affects hyaluronic acid production<\/h3>\n<\/li>\n<\/ul>\n<p>Hyaluronic acid is a glycosaminoglycan: a large, water-binding molecule found in the extracellular matrix\u2014the material surrounding cells. Hyaluronic acid is one of the body\u2019s important moisturizing molecules. It helps tissues retain water and maintain their cushioning, flexibility, and viscoelasticity. Depending on its location, such as vaginal tissue, it also contributes to lubrication. In skin and mucosal tissues, it contributes to a hydrated extracellular environment. And in joints, it helps give synovial fluid the viscoelastic properties needed for smooth movement and fluid retention.<\/p>\n<p>In our younger years, estradiol maintains hyaluronic acid and other glycosaminoglycans. When estradiol declines, hyaluronic acid and the other glycoaminoglycans production and maintenance declines, reducing tissue hydration and lubrication affecting not only joint health but dryness in skin, eyes, mucosal tissue lining the sinuses, mouth, GI tract, and vagina.<\/p>\n<p>Men also need estradiol signaling to maintain hyaluronic acid. Most estradiol in men is supplied through conversion of testosterone to estradiol by the enzyme aromatase.<\/p>\n<p><strong>THE BOTTOM LINE:<\/strong> Testosterone has anabolic effects to build both bone and muscle in both sexes; estradiol helps maintain bone in both sexes by facilitating calcium being absorbed and deposited into bone and preventing excess bone breakdown in the remodeling process needed to maintain strong bones.\u00a0 The combined musculoskeletal benefits of both estradiol and testosterone involve maintain healthy muscle, bone, and connective tissue plus pain regulation and improving lubrication of joints.<\/p>\n<ul>\n<li>\n<h3>Progesterone: Crucial differences between pregnancy and menopause effects for women<\/h3>\n<\/li>\n<\/ul>\n<p>Studies on progesterone over the years have found minimal benefits on building bone and muscle, but progesterone has significant benefits to increase ligament laxity (elasticity or \u201cstretchiness) in women during the luteal phase of the menstrual cycle in ovulating women and even more pronounced in pregnancy.\u00a0 Increasing the elasticity of ligaments in the pelvic girdle allows for expansion of the pelvic bones during pregnancy to accommodate the growing baby and then allow the pelvic bones to separate enough for the baby\u2019s head to pass through the birth canal during delivery.\u00a0 That is major adaptive advantage during pregnancy.<\/p>\n<p>Menopause, however, is a different story and older women have very different needs from women during pregnancy.\u00a0 Ligaments that are looser, or more elastic, during the luteal phase of the menstrual cycle is one of the factors that contributes to more frequent knee and hip injuries in young women athletes. In older women taking daily progesterone for hormone therapy, progesterone-induced ligament laxity can be a significant problem leading to knee, hip, ankle, shoulder and elbow injuries, since older women are losing tendon and ligament strength to support their joints as they age.\u00a0 Progesterone excess in older women has many negative effects, particularly if they also have inadequate estradiol and testosterone benefits to build stronger muscles, tendons and ligaments.<\/p>\n<p><strong>BOTTOM LINE: Hormone changes can alter tissue biology, strength, elasticity, inflammatory activity, hyaluronic acid quality, and pain processing.\u00a0 All of these factors can contribute to joint pain that may be helped with properly designed hormone interventions integrated with other approaches.<\/strong><\/p>\n<h3>Why Joint Pain Increases Around Menopause<\/h3>\n<p>During the menopause transition, or early menopause triggered by the COVID shots for example, the decline and fluctuations in estradiol leads to changes in the environment in which joints, tendons, and muscles function. At the same time, age-related changes, previous injuries, medication side effects, developing osteoarthritis, sleep disruption, and reduced activity also contribute to joint pain symptoms.\u00a0 Multiple mechanisms can overlap and intensify combined effects:<\/p>\n<ul>\n<li>Changes in connective-tissue turnover and mechanical behavior.<\/li>\n<li>Changes in inflammatory and sensory-nerve signaling.<\/li>\n<li>Reduced muscular capacity to tolerate everyday activity.<\/li>\n<li>Disrupted sleep that impairs normal tissue repair overnight<\/li>\n<li>Greater sensitivity to an existing joint or tendon problem.<\/li>\n<\/ul>\n<p>This helps explain why a woman may report new widespread aching or stiffness around menopause without having a single new injury. It also explains why hormonal changes can aggravate a problem that was previously manageable.<\/p>\n<h3>Can menopausal hormone therapy help?<\/h3>\n<p>In my medical practice, with optimal hormone therapy tailored to an individual\u2019s needs and activity level, I typically see significant reduction in joint pain, particularly with the integrated approach combining the strategies I am discussing here. The degree of benefit depends in large part on type of menopausal hormone therapies used and whether the doses are titrated to optimal levels for an individual woman.\u00a0 For example, in my medical practice since 1985 I have only used bioidentical forms of ovarian hormones (whether FDA-approved commercial ones or individually compounded options), so I have seen significantly positive results on muscle and joint pain reduction with hormone therapy in my patients.\u00a0 But in The Women\u2019s Health Initiative (WHI), published in 2002 that gave hormone therapy such a bad rap, there were not such significant results.\u00a0 I think that is directly related to the very different hormone products used in that study.\u00a0 The WHI used conjugated equine estrogens derived from pregnant mare\u2019s urine that provided a lot of horse estrogens and very little of the human 17-beta estradiol, and it was given with a high dose synthetic progestin (Provera, or medroxyprogesterone acetate) that negated on average 50-60% of the estrogen benefits.\u00a0 Even in the conjugated equine estrogen only arm of the WHI (in women had a hysterectomy and did not need progestin therapy), there was only about a 3% positive difference between joint pain in women on the horse estrogen compared to women on placebo.\u00a0 Pain severity was also slightly lower with estrogen. So the results were encouraging but not the marked improvements I have seen over my career treating women with bioidentical hormones and optimal dosing tailored to each patient rather than a one-size-fits-all dose. And I have never prescribed the oral conjugated equine estrogens.\u00a0 Unfortunately, to this day, we have never had a head-to-head study comparing oral conjugated equine estrogens and bioidentical 17-beta estradiol products.<\/p>\n<h3>Cancer treatment: major impact on hormone balance\u2014A factor in musculoskeletal pain<\/h3>\n<p>Cancer therapies that suppress hormone production or signaling provide a clinically important example of just how important the hormone-pain connection can be. Many of the cancer chemotherapy agents as well as radiation treatments for cancer cause early menopause in women or hypogonadism (low testosterone) in men undergoing cancer treatment. The resulting hormone losses for men and women can be significant factors in new onset joint pain, muscle soreness, bone loss, loss of connective tissue strength, and sleep disruption\u2014all of which contribute to pain.<\/p>\n<ul>\n<li><strong>Breast cancer: aromatase inhibitors versus tamoxifen<\/strong><\/li>\n<\/ul>\n<p>Aromatase inhibitors\u2014anastrozole, letrozole, and exemestane\u2014block the enzyme that converts testosterone to estradiol in the overall pathway that increases estrogen synthesis. Many patients on taking these drugs develop a recognized syndrome involving joint pain (shoulder, knees, hips, low back), morning stiffness, tendon irritation, \u201ctrigger finger,\u201d \u201ctennis elbow,\u201d or carpal tunnel symptoms.<\/p>\n<p>Tamoxifen works differently. It blocks estrogen receptors in breast tissue but can exert estrogen-like effects elsewhere, particularly in postmenopausal bone. It generally causes fewer joint symptoms than aromatase inhibitors, although it can still cause musculoskeletal pain. In the \u00a0\u2018Arimidex\u2019, Tamoxifen, Alone or in Combination (ATAC) trial, joint symptoms occurred in 35.6% of anastrozole users and 29.4% of tamoxifen users.<\/p>\n<ul>\n<li><strong>Prostate cancer: lowering testosterone also affects estradiol<\/strong><\/li>\n<\/ul>\n<p>Androgen-deprivation therapy, or ADT, reduces testosterone production as well as androgen signaling. Men on ADT commonly experience significant loss of muscle mass, accelerated bone loss, increased fat mass, and weakness, loss of stamina, and increased fractures. Lower testosterone also reduces the substrate available for estradiol production, which adversely affects memory, sleep and further contribute to musculoskeletal symptoms and reduced tolerance for activity. For both groups, the goal is to manage symptoms while preserving effective cancer treatment. Patients should not stop hormone-blocking therapies on their own, and should not add reproductive hormones on their own without extensive discussion with their personal physicians.<\/p>\n<p>Current guidelines in the US do not recommend hormone therapy for men or women after treatment for prostate or breast cancer, but actual research data actually shows that hormone therapy may have benefits and not increase risk of cancer recurrence.\u00a0 These are lengthy discussions beyond the scope of this short Health Tip, but they are discussions and review of the medical studies that I have with my own men and women patients who want to consider hormone therapy after successfully treated cancer.\u00a0\u00a0 This is also where alternative pain management strategies including nutrition, exercise and specific nutraceuticals can play an important role.<\/p>\n<h3>FISH OIL: complementary strategy to reduce pain and inflammatory signaling<\/h3>\n<p>Adding Fish Oil is one of my pain-reduction strategies for appropriate patients.\u00a0 Fish oil supplies EPA and DHA, long-chain omega-3 fatty acids that become incorporated into cell membranes. They change the substrates available for producing inflammatory lipid signals and provide starting materials for pathways that help resolve inflammation.<\/p>\n<p><strong>Mechanism 1: changing the inflammatory \u201cmessage mix\u201d<\/strong><\/p>\n<p>EPA competes with arachidonic acid in enzyme pathways that produce eicosanoids\u2014short-lived lipid messengers involved in inflammation and pain. This changes the balance of mediators that sensitize sensory nerves. If those nerves become less reactive, ordinary movements hurt less even when the underlying joint structure remains unchanged.<\/p>\n<p><strong>Mechanism 2: supplying materials for inflammation resolution<\/strong><\/p>\n<p>EPA and DHA serve as precursors for specialized mediators that reduce inflammation:<\/p>\n<ul>\n<li>EPA contributes to E-series resolvins.<\/li>\n<li>DHA contributes to D-series resolvins, protectins, and maresins.<\/li>\n<\/ul>\n<p>These molecules help decrease inflammatory pain by coordinating the clearance of inflammatory cells and debris that trigger pain rather than simply blocking inflammation\u2019s initiation.<\/p>\n<p><strong>Mechanism 3: reducing nerve sensitization<\/strong><\/p>\n<p>In laboratory and animal research, resolvins reduce activity in pain-related ion channels and dampen exaggerated spinal signaling. These findings help explain the pain relief effects of fish oil in humans.<\/p>\n<p><strong>Fish Oil may complement estradiol\u2019s pain-reducing benefits<\/strong><\/p>\n<p>Estradiol has multiple effects on pain pathways and significant effects to help reduce pain overall via modifying hormone-sensitive inflammatory and neural pathways, while EPA and DHA alter lipid signaling and supply inflammation-resolution substrates. Their actions complement one another and are a combination I often find beneficial in my menopausal patients.<\/p>\n<p>Based on my clinical experience over many years of medical practice seeing improved pain after adding EPA\/DHA to a stable estradiol regimen,\u00a0 I do think it is worth considering even if we don\u2019t have controlled trials confirming that estradiol plus fish oil provides a synergistic joint-pain benefit in menopausal women. Here is where mechanistic plausibility and clinical experience provides guidance for shared decision-making with patients who need help now, before we have formal studies to confirm physiologically plausible benefits.<\/p>\n<h3>\nMy recommendations: TruOmegaPure\u2122\u00a0 and TruSynovial Support\u2122.<\/h3>\n<p>If you want to try adding Fish Oil, I don\u2019t recommend just any fish oil off the drug store or warehouse shelf.\u00a0 It is important to select a product with documented sourcing and purity of high quality ingredients and formulated in a way to enhance bioavailability.\u00a0 I found two products that I think meet these standards to put in the Truth for Health foundation store:\u00a0 TruOmega Pure and TruSynovial Support\u2122.<\/p>\n<p><a href=\"https:\/\/shoptruthforhealth.com\/products\/trusynovial_support?variant=47066407010626\"><img loading=\"lazy\" decoding=\"async\" class=\"aligncenter wp-image-11018 size-large\" src=\"data:image\/gif;base64,R0lGODlhAQABAAAAACH5BAEKAAEALAAAAAABAAEAAAICTAEAOw==\" data-layzr=\"https:\/\/www.truthforhealth.org\/wp-content\/uploads\/2026\/10\/Healthy-Joints-Balanced-Hormones-1024x683.jpg\" alt=\"\" width=\"1020\" height=\"680\" \/><\/a><\/p>\n<table width=\"100%\">\n<tbody>\n<tr>\n<td>\n<table width=\"100%\">\n<tbody>\n<tr>\n<td><strong>TruOmegaPure\u2122 : a superior delivery option for EPA and DHA<\/strong><\/p>\n<p>TruOmegaPure\u2122 is a monoglyceride fish-oil formulation designed to improve EPA\/DHA absorption compared with standard equivalent ethyl-ester formulation. In fact studies found that TruOmegaPure\u2122\u00a0 delivers three times the amount of EPA and DHA.<\/p>\n<p><a href=\"https:\/\/shoptruthforhealth.com\/products\/truomegapure-epa-dha-dpa?variant=46450453774658\"><strong>TruOmegaPure\u2122<\/strong><\/a>\u00a0has a number of unique features that I think are important to consider:<\/p>\n<ol>\n<li>It contains\u00a0<em>all three essential fatty acids<\/em>: the two found in cold-water fish (EPA, or eicosapentaenoicacid and DHA (docosahexaenoic acid), plus it contains DPA, or\u00a0docosapentaenoic acid), the intermediate fatty acid between EPA and DHA that has health benefits that previously were thought to only occur with EPA and DHA.<\/li>\n<li><a href=\"https:\/\/shoptruthforhealth.com\/products\/truomegapure-epa-dha-dpa?variant=46450453774658\"><strong>TruOmegaPure\u2122<\/strong><\/a>\u00a0uses the novel MaxSimil Platform, an innovative monoglyceride delivery system that enhances absorption of lipid-based and lipid-soluble nutraceutical and food ingredients. This delivery system ensures the fish oil is significantly better absorbed \u2013as much as 300% in some studies\u2014compared to other fish oil preparations. The MaxSimil formulation is directly assimilated in intestinal tract for maximum benefit, and less likely to cause diarrhea side effects! Since the MaxSimil delivery system bypasses the body\u2019s normal fat digestion pathways,\u00a0<a href=\"https:\/\/shoptruthforhealth.com\/products\/truomegapure-epa-dha-dpa?variant=46450453774658\"><strong>TruOmegaPure\u2122<\/strong><\/a>\u00a0is an especially effective omega-3 fatty acid supplement for individuals with digestive, pancreatic, or gall bladder challenges.<\/li>\n<li>MaxSimil EPA and DHA forms showed superior activity on\u00a0colorectal,\u00a0breast,\u00a0lung, and\u00a0prostate\u00a0diseased cell-line growth inhibition and cytokine production when compared to control, corn oil, krill oil, or the parent forms ethyl ester (EE) EPA and ethyl ester (EE) DHA in patients with\u00a0rheumatoid arthritis\u00a0and\u00a0asthma. Researchers postulated that the observed superior effects of MaxSimil EPA and DHA forms were the result of enhanced absorption and later confirmed this in a clinical study with 20 healthy adults.<\/li>\n<li>MaxSimil forms of the two fatty acids, EPA and DHA, showed a positive impact on supplemented patients for benefits on\u00a0cardiovascular health parameters, including blood pressure, heart rate, serum lipid levels, cytokine production, aortic wall thickness, and a DHA:AA ratio in aortic tissue, which correlated with the production of\u00a0resolvin D2 and D3 metabolites\u00a0which aid in the bodies \u201cclean up\u201d response to inflammation.*<\/li>\n<li><a href=\"https:\/\/shoptruthforhealth.com\/products\/truomegapure-epa-dha-dpa?variant=46450453774658\"><strong>TruOmegaPure\u2122<\/strong><\/a>\u00a0fish oil is non-GMO, certified sustainable from Scandinavia, and antibiotic-free. Additionally, it is eco-friendlybecause the greater absorption of EPA and DHA ultimately means that fewer grams of fish oil need to be harvested for the same benefit.<\/li>\n<li><a href=\"https:\/\/shoptruthforhealth.com\/products\/truomegapure-epa-dha-dpa?variant=46450453774658\"><strong>TruOmegaPure\u2122<\/strong><\/a>\u00a0contains monoglyceride fish oil in an enteric-coated fish-gelatin capsule with no additional ingredients, carriers, or excipients.<\/li>\n<li><a href=\"https:\/\/shoptruthforhealth.com\/products\/truomegapure-epa-dha-dpa?variant=46450453774658\"><strong>TruOmegaPure\u2122<\/strong><\/a>\u00a0is manufactured in the US in a cGMP facility and meets the highest standards for purity, potency, and freshness.<\/li>\n<\/ol>\n<p><strong>TruSynovial Support\u2122: with green-lipped mussels<\/strong><\/p>\n<p><a href=\"https:\/\/shoptruthforhealth.com\/products\/trusynovial_support?variant=47066407010626\"><strong>TruSynovial Support\u2122<\/strong><\/a> contains a unique formula with New Zealand Green Lipped Mussel Extract sourced from unpolluted waters off New Zealand for greater purity. Green-lipped mussels\u00a0(<em>Perna canaliculus<\/em>) contain GAGs (glycosaminoglycans), the principal components of cartilage and synovial fluid, as well\u00a0as eicosatetraenoic acid, which promotes a healthy joint environment. <a href=\"https:\/\/shoptruthforhealth.com\/products\/trusynovial_support?variant=47066407010626\"><strong>TruSynovial Support\u2122<\/strong> <\/a>contains a combination of ingredients including green-lipped mussel, MSM, glucosamine, chondroitin, and hyaluronic acid.<\/p>\n<p>Green-lipped mussels came to the attention of the scientific community in the 1960s and 70s because the\u00a0Maori\u2019s were known for being more flexible and agile\u00a0as they aged than other New Zealanders.\u00a0<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/26462365\/\" data-saferedirecturl=\"https:\/\/www.google.com\/url?q=https:\/\/pubmed.ncbi.nlm.nih.gov\/26462365\/&amp;source=gmail&amp;ust=1792967060238000&amp;usg=AOvVaw1okpd4pSTVrk1FJXs1gOHJ\">Laboratory research<\/a>\u00a0has shown that green-lipped mussel extract reduces inflammation at the cellular level and appear to help the body repair and restore cartilage in arthritic joints. Doctors have been telling patients for years that cartilage doesn\u2019t heal and once cartridge is lost it cannot be replaced. This\u00a0research on the green lip mussel\u00a0extract indicates the opposite, so I highly recommend you give it a try!\u00a0 For more detailed product research references please refer to my original health tips on both of these outstanding options to help reduce inflammation and joint pain:<\/p>\n<p><a href=\"http:\/\/www.truthforhealth.org\/es\/2024\/11\/health-tip-from-dr-vliet-truomegapure\/\" data-saferedirecturl=\"https:\/\/www.google.com\/url?q=http:\/\/www.truthforhealth.org\/2024\/11\/health-tip-from-dr-vliet-truomegapure\/&amp;source=gmail&amp;ust=1792967060238000&amp;usg=AOvVaw3erlxh4H-Z9B7Ivd5mgM32\"><strong>HEALTH TIP from Dr. Vliet \u2013 TruOmegaPure<\/strong><\/a><br \/>\n<a href=\"http:\/\/www.truthforhealth.org\/es\/2024\/01\/health-tip-from-dr-vliet-trusynovial-support\/\" data-saferedirecturl=\"https:\/\/www.google.com\/url?q=http:\/\/www.truthforhealth.org\/2024\/01\/health-tip-from-dr-vliet-trusynovial-support\/&amp;source=gmail&amp;ust=1792967060238000&amp;usg=AOvVaw2GCM8y0gS6pagrsw_RLX02\"><strong>Health Tip from Dr. Vliet \u2013 TruSynovial Support<\/strong><\/a><\/p>\n<p><strong>Dr. Vliet\u2019s Lifestyle Strategies for Reducing Joint Pain<\/strong><\/p>\n<p><strong>Movement remains the foundation<\/strong><strong>!<\/strong><\/p>\n<p>A supplement cannot provide the strength, coordination, and loading tolerance that exercise develops. YOU\u2019VE GOT TO MOVE TO KEEP MOVING!\u00a0 In the HOPE randomized trial, women with aromatase inhibitor\u2013related joint symptoms followed a program targeting 150 minutes weekly of aerobic exercise plus twice-weekly strength training. After 12 months, worst joint pain decreased by 1.6 points\u201429%\u2014while the usual-care group experienced a small increase.\u00a0 \u00a0Exercise also helps men receiving ADT preserve physical function and address treatment-related muscle and bone loss and fatigue.<\/p>\n<p><strong>Build a balanced routine<\/strong><\/p>\n<ol>\n<li>Start with tolerable aerobic movement. Walking, cycling, and water-based activity can improve conditioning without requiring high-impact exercise.<\/li>\n<li>Add progressive resistance training. Begin at a manageable level and increase gradually; permanent restriction to very light weights may limit strength gains.<\/li>\n<li>Maintain mobility. Gentle range-of-motion work such as easy stretching and chair yoga can reduce stiffness and allow for more comfortable movement.<\/li>\n<li>Include balance and movement control. These become particularly important when weakness or treatment-related bone loss increases fall risk.<\/li>\n<li>Use yoga or Pilates thoughtfully. They can help with mobility, body-weight resistance, and body awareness. Yoga has some direct research support for arthritis related symptoms although Pilates-specific evidence is less the mechanisms of action are similar and both are beneficial with proper instruction.<\/li>\n<\/ol>\n<p>Note: Pain should guide modification, not automatically eliminate activity. In general, if you experience a new or sudden sharp pain \u2013 stop activity seek medical guidance. If you feel a more general pain decrease intensity of activity. If the pain goes away maintain activity at that level, if it continues discontinue activity for that day.\u00a0 A physical therapist can identify when a painful shoulder, hand, knee, or hip needs a more targeted plan.<\/p>\n<p><strong>Support the system around the joint<\/strong><\/p>\n<p>An effective and sustainable plan also needs to address nutrition, recovery, and the barriers that keep people from moving.<br \/>\nA plant-forward, whole food type of meal plan with adequate protein is not only anti-Inflammatory and supports general health it also is important for muscle and bone maintenance, body composition that helps with pain management. Gradual fat loss helps when excess weight contributes to excess loading on the joints and joint pain. Sleep problems, fatigue, and distress also need to be addressed because they can interfere with recovery, healing and rehabilitation and increase pain\u2019s impact.<br \/>\nAll of these measures support recovery; individually they may not be a standalone cure for hormone-related pain but each contributes an important piece in helping reduce joint pain.<\/p>\n<p><strong>A practical path forward<\/strong><\/p>\n<p>The hormone\u2013joint connection is real, and I think is an important addition to an overall, integrated pain management plan. But \u201cjoint pain\u201d is NOT a single disease with a single remedy. Estradiol and testosterone influence tissue function and pain processing in both sexes, while menopause, hypogonadism, and cancer treatment create different clinical situations that require individualized approaches. There are common pain-reducing approaches that can work in all these situations, but it will take a thorough evaluation of the many root causes and then begin a systematic plan to address the causes identified.\u00a0 I recommend a comprehensive evaluation that identifies the pain source, reviews hormonal-metabolic-inflammation markers, considers replacement therapy, lifestyle strategies, appropriate exercise to protect muscle and bone and supports sustainable movement, and the inclusion of a high quality fish oil supplement and other targeted supplements.\u00a0 My two go to products are: <strong>TruOmegaPure\u2122<\/strong> and <strong>TruSynovial Support\u2122<\/strong> that have helped many of my patients achieve measurable improvements in comfort and function.<\/p>\n<p>As you put all the pieces together that I have described today, I encourage you to consider our other natural medicines with our top quality, cGMP-compliant professional formulas:<strong><em> TruMitochondrial\u2122 Boost,\u00a0 TruNAC\u2122, Tru BioD3, Tru B\u2122 Complex Full Spectrum, TruZinc\u2122, TruC with BioFlavonoids\u00a0 <\/em>(Natural sourced Vitamin<em> C with complete Bioflavonoids), and TruProBiotic\u2122 Daily <\/em><\/strong>to replenish critical bifidobacteria depleted by COVID shots, viral illnesses, and antibiotic therapy.<\/p>\n<p>All Truth for Health Foundation Products Meet or Exceed cGMP Quality Standards, the highest quality standard for supplements sold in the USA. <strong><em>For more information, references from studies are listed in the Product Data Sheets for each product, available on our website.<\/em><\/strong>\u00a0 Check us out at <a href=\"http:\/\/www.TruthforHealth.org\" data-saferedirecturl=\"https:\/\/www.google.com\/url?q=http:\/\/www.TruthforHealth.org&amp;source=gmail&amp;ust=1792967060238000&amp;usg=AOvVaw0-k5w9zUtVDQN1LPcLJY5u\">www.TruthforHealth.org<\/a> Click on tab for Store.\u00a0 OR <a href=\"http:\/\/www.shopTruthforHealth.com\" data-saferedirecturl=\"https:\/\/www.google.com\/url?q=http:\/\/www.shopTruthforHealth.com&amp;source=gmail&amp;ust=1792967060238000&amp;usg=AOvVaw12dTnEoI1ot8jpME2kPDnw\">www.shopTruthforHealth.com<\/a><\/p>\n<p><strong>CAUTION:<\/strong> As always, we urge you to avoid supplements without checking knowledgeable sources to evaluate your medical situation, proper lab tests to verify what is needed, and to make sure to avoid adverse interactions with prescription medicines and other supplements you take.\u00a0 Under medical practice regulations, we are unable to answer individual medical questions or make specific individual supplement recommendations for people who are not established patients of Dr. Vliet\u2019s independent medical practice (<a href=\"http:\/\/www.ViveLifeCenter.com\" data-saferedirecturl=\"https:\/\/www.google.com\/url?q=http:\/\/www.ViveLifeCenter.com&amp;source=gmail&amp;ust=1792967060238000&amp;usg=AOvVaw0Iy1NFKgfj6DDgEHqoljuF\">www.ViveLifeCenter.com<\/a>).<\/p>\n<p><strong>To Your good health and improving resilience!<\/strong><br \/>\n<strong>Elizabeth Lee Vliet, MD<\/strong><\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<table width=\"100%\">\n<tbody>\n<tr>\n<td>\n<table width=\"100%\">\n<tbody>\n<tr>\n<td><a href=\"https:\/\/www.truthforhealth.org\/es\/category\/health-tips\/\"><u><strong>C<\/strong><em><strong>lick here to read Dr. Vliet\u2019s Health Tips<br \/>\non these and more products.<\/strong><\/em><\/u><\/a><\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<p>&nbsp;<\/p>","protected":false},"excerpt":{"rendered":"<p>The Hormone &#8211; Joint Pain Connection for Men and Women Joint pain is commonly written off by most doctors as just \u201carthritis\u201d because you are getting older.\u00a0 But the truth &hellip; <\/p>","protected":false},"author":21,"featured_media":11017,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":""},"categories":[222],"tags":[],"class_list":["post-11016","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-health-tips","fadeIn","image-hover-transition-effect","latest_post"],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v28.5 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>Dr. Vliet\u2019s Health Tip: Estradiol, Testosterone and Painful Joints\u2014Connecting the Dots - Truth for Health Foundation<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.truthforhealth.org\/es\/2026\/10\/dr-vliets-health-tip-estradiol-testosterone-and-painful-joints-connecting-the-dots\/\" \/>\n<meta property=\"og:locale\" content=\"es_MX\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Dr. Vliet\u2019s Health Tip: Estradiol, Testosterone and Painful Joints\u2014Connecting the Dots - Truth for Health Foundation\" \/>\n<meta property=\"og:description\" content=\"The Hormone &#8211; Joint Pain Connection for Men and Women Joint pain is commonly written off by most doctors as just \u201carthritis\u201d because you are getting older.\u00a0 But the truth &hellip;\" \/>\n<meta property=\"og:url\" content=\"https:\/\/www.truthforhealth.org\/es\/2026\/10\/dr-vliets-health-tip-estradiol-testosterone-and-painful-joints-connecting-the-dots\/\" \/>\n<meta property=\"og:site_name\" content=\"Truth for Health Foundation\" \/>\n<meta property=\"article:published_time\" 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