{"id":10524,"date":"2026-01-13T16:32:28","date_gmt":"2026-01-13T16:32:28","guid":{"rendered":"https:\/\/www.truthforhealth.org\/?p=10524"},"modified":"2026-01-13T16:32:28","modified_gmt":"2026-01-13T16:32:28","slug":"dr-vliets-health-tipfrom-pomegranate-power-to-cardiac-amyloid-clearance-ellagic-acids-breakthrough-for-long-covid-vax-injury-deadly-heart-deposits","status":"publish","type":"post","link":"https:\/\/www.truthforhealth.org\/es\/2026\/01\/dr-vliets-health-tipfrom-pomegranate-power-to-cardiac-amyloid-clearance-ellagic-acids-breakthrough-for-long-covid-vax-injury-deadly-heart-deposits\/","title":{"rendered":"Dr. Vliet\u2019s Health Tip:From Pomegranate Power to Cardiac Amyloid Clearance: Ellagic Acid&#8217;s Breakthrough for \u201cLong COVID\u201d, Vax Injury &#038; Deadly Heart Deposits"},"content":{"rendered":"<p>\u00a9 by Elizabeth Lee Vliet MD and Kathy Kresnik<\/p>\n<table width=\"100%\">\n<tbody>\n<tr>\n<td>\n<table width=\"100%\">\n<tbody>\n<tr>\n<td>\u201cLong COVID\u201d and debilitating damage from COVID \u201cvaccines\u201d plaque millions of people around the world, creating complex clinical challenges for medical professionals. Symptoms range from the extreme of sudden death and turbo-cancer to survivable, but often disabling, chronic fatigue, \u201cbrain fog\u201d and more serious cognitive decline to cardiovascular complications such as amyloid micro-clots and <a href=\"https:\/\/pmc.ncbi.nlm.nih.gov\/articles\/PMC8280690\/\" data-saferedirecturl=\"https:\/\/www.google.com\/url?q=https:\/\/pmc.ncbi.nlm.nih.gov\/articles\/PMC8280690\/&amp;source=gmail&amp;ust=1768165933932000&amp;usg=AOvVaw3IXfUg-iq_QvZrFFINrrRP\">cardiomyopathy<\/a>. I continue to search for safe, effective early medical and natural interventions to give my patients more options.<\/p>\n<p>Recent reports led me to explore more about <strong>polyphenols, <\/strong>a frequent topic of my seminars and health tips.\u00a0 But I also looked closer at <strong>ellagic acid,<\/strong> a specific polyphenol component <em>naturally present in pomegranate, berries, and nuts<\/em>, some of my favorite foods to eat myself and to recommend for patients. Interest in these foods is nothing new, and they were even featured in HHS Secretary Kennedy\u2019s new food recommendations just released, specifically because their broad-spectrum <a href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0022316622084656?via%3Dihub\" data-saferedirecturl=\"https:\/\/www.google.com\/url?q=https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0022316622084656?via%253Dihub&amp;source=gmail&amp;ust=1768165933933000&amp;usg=AOvVaw1s_9D4n-g9oNE36GEtZguG\">antioxidant and anti-inflammatory properties<\/a> have so many health benefits.<\/p>\n<p>But I wanted to focus today\u2019s health tip on <em>new evidence of ellagic acid\u2019s mechanisms, preclinical and clinical data<\/em>, relevant cellular pathways <em>related to symptoms and complications from long COVID and post-COVID vaccine injuries<\/em>, as well as several important heart complications and other common chronic medical problems.\u00a0 My Health Tip today provides practical suggestions for your diet and a unique new product for ellagic acid supplementation.<\/p>\n<p><strong>What is Ellagic Acid?<\/strong><\/p>\n<p>Ellagic acid is a polyphenolic compound structurally notable for its antioxidant potency and anti-inflammatory capacity. Ellagic acid is classified as a dilactone of <em>hexahydroxydiphenic acid,<\/em> originating from gallic acid via oxidative coupling. Its dietary sources include <em>pomegranate<\/em> (especially whole fruit, peel-inclusive extracts),<em> cloudberries, cranberries, strawberries, raspberries, walnuts, and pecans<\/em>. In nature, ellagic acid occurs both in free form and as part of larger ellagitannin molecules, which are hydrolyzed in the gut to release bioactive ellagic acid. This conversion is central to its bioavailability and potential health effects, particularly in the context of viral and <a href=\"https:\/\/pmc.ncbi.nlm.nih.gov\/articles\/PMC8885183\/\" data-saferedirecturl=\"https:\/\/www.google.com\/url?q=https:\/\/pmc.ncbi.nlm.nih.gov\/articles\/PMC8885183\/&amp;source=gmail&amp;ust=1768165933933000&amp;usg=AOvVaw3uSlny9PVbQhYwjTFvRMM_\">inflammatory conditions<\/a>.<\/p>\n<p><strong>Mechanisms of Action: Antioxidant, Anti-Inflammatory, and Anti-Fibrotic Effects<\/strong><\/p>\n<p>Ellagic acid\u2019s therapeutic potential is due to its ability to modulate oxidative stress, inflammation, and fibrotic processes\u2014pathways implicated in the pathogenesis of long COVID, post-COVID vaccine injury and cardiovascular injuries, including amyloid deposits. Ellagic acid\u2019s actions are <a href=\"https:\/\/pmc.ncbi.nlm.nih.gov\/articles\/PMC10180134\/\" data-saferedirecturl=\"https:\/\/www.google.com\/url?q=https:\/\/pmc.ncbi.nlm.nih.gov\/articles\/PMC10180134\/&amp;source=gmail&amp;ust=1768165933933000&amp;usg=AOvVaw3NBJNgVgaoiZCW_eLsPrBU\">multifaceted<\/a>:<\/p>\n<ul>\n<li><strong>Antioxidant:<\/strong> It scavenges reactive oxygen species (ROS), replenishes endogenous antioxidants, and reduces oxidative tissue damage\u2014a critical factor in viral illness recovery and organ protection.<\/li>\n<li><strong>Anti-Inflammatory:<\/strong> Ellagic acid suppresses neutrophil-driven inflammation, limits the release of pro-inflammatory cytokines (e.g., TNF-\u03b1, IL-6, IL-1\u03b2), and dampens the cytokine storm phenomenon seen in severe viral infections and long COVID.<\/li>\n<li><strong>Anti-Fibrotic:<\/strong> It modulates fibrotic pathways, such as TGF-\u03b21 signaling, reducing extracellular matrix remodeling and hypertrophic scarring, which may be relevant to post-viral cardiomyopathy and protein aggregation disorders, such as amyloidosis.<\/li>\n<li><strong>Preclinical studies suggest that ellagic acid supports endothelial function by downregulating adhesion molecules like VCAM1 and ICAM1, potentially helping to reduce microvascular injury, including amyloid-like clot formation.<\/strong> Ellagic acid\u2019s actions are compelling, but at this time, most evidence remains theoretical or derived from non-COVID disease models.<\/li>\n<\/ul>\n<p><strong>Cellular Pathways Modulated by Ellagic Acid in Viral Infections<\/strong><\/p>\n<p>Ellagic acid primarily targets host cellular pathways rather than directly binding or inactivating viral particles. Key mechanisms <a href=\"https:\/\/pmc.ncbi.nlm.nih.gov\/articles\/PMC4052798\/\" data-saferedirecturl=\"https:\/\/www.google.com\/url?q=https:\/\/pmc.ncbi.nlm.nih.gov\/articles\/PMC4052798\/&amp;source=gmail&amp;ust=1768165933933000&amp;usg=AOvVaw3aGSOhysd6MBfVT0ieRfz7\">include<\/a>:<\/p>\n<ul>\n<li><strong>NF-\u03baB Pathway:<\/strong> Inhibition of this central inflammatory cascade reduces transcription of cytokines (TNF-\u03b1, IL-6, IL-1\u03b2) and cyclooxygenase-2 (COX-2), which in turn reduces cytokine storms and systemic inflammation.<\/li>\n<li><strong>MAPK\/AKT1 Pathways:<\/strong> Downregulation of MAPK3, AKT1, and related kinases dampens cell signaling involved in inflammation, leukocyte adhesion, and endothelial dysfunction.<\/li>\n<li><strong>IRF7 and Other Immune Modulators:<\/strong> Ellagic acid limits vascular permeability, tissue remodeling, and neuroinflammation by interacting with IRF7, VEGFA, and MMPs.<\/li>\n<li><strong>Antiviral Replication Blockade:<\/strong> Ellagic acid interferes with viral RNA replication via host cell factors, as demonstrated in HRV-4 and PEDV models, and inhibits enzymes like HIV-1 integrase without directly altering viral genomes.<\/li>\n<\/ul>\n<p><strong>These mechanisms collectively suggest a host-targeted approach that can reduce viral exploitation of cellular machinery, protect against tissue injury, and modulate immune responses relevant to post-viral syndromes.<\/strong><\/p>\n<p><strong>Ellagic Acid Evidence in Disease Models: Long COVID, Amyloid Microclots, and Cardiomyopathy<\/strong><\/p>\n<p><strong>Long COVID and COVID Vaccine Injury:<\/strong> Theoretical promise for ellagic acid in long COVID and post-vaccine syndromes stems from its ability to mitigate oxidative stress, reduce inflammation, and inhibit fibrotic remodeling. These benefits target tissue damage that causes fatigue, cognitive impairment, and cardiovascular dysfunction (e.g., amyloid clots, cardiomyopathy).\u00a0 <em>Direct clinical evidence is still lacking, mainly because doctors are still NOT making the connection between the COVID shots and these clinical problems patients are reporting<\/em>.<\/p>\n<p><strong>Amyloid Microclots:<\/strong> Most research centers on neurofibrillary pathology in Alzheimer\u2019s disease, where ellagic acid reduces amyloid precursor protein expression and related neurotoxicity.\u00a0 We don\u2019t yet have specific studies that look at COVID shot caused microclot formation, again <em>because doctors are still NOT making the connection between the COVID shots and these clinical problems.<\/em><\/p>\n<p><strong>Cardiomyopathy and Fibrosis:<\/strong> In preclinical models, ellagic acid reduces extracellular matrix remodeling and hypertrophic scarring, suggesting potential to address post-viral cardiac fibrosis and protein aggregation. Its modulation of SARS-CoV-2 proteases and host immune responses supports adjunctive potential, but human trials are still needed.<\/p>\n<p><strong>Cytokine Storm Attenuation:<\/strong> Evidence from in vivo models (malaria and multiple sclerosis) demonstrates that ellagic acid suppresses pro-inflammatory cytokines and restores barrier integrity.\u00a0 One human trial in MS found decreased levels of IFN-\u03b3 and IL-17 in addition to improved clinical scores. These findings are relevant to hyperinflammatory states but have not yet been directly extended to COVID-19 illness or long COVID.<\/p>\n<p><strong>Summary of Key <\/strong><a href=\"https:\/\/pmc.ncbi.nlm.nih.gov\/articles\/PMC8885183\/#sec6\" data-saferedirecturl=\"https:\/\/www.google.com\/url?q=https:\/\/pmc.ncbi.nlm.nih.gov\/articles\/PMC8885183\/%23sec6&amp;source=gmail&amp;ust=1768165933933000&amp;usg=AOvVaw1QgifF0e4FfO013ZB6l5fL\"><strong>Clinical Trials with Ellagic Acid<\/strong><\/a><strong>:<\/strong><\/p>\n<table width=\"617\">\n<tbody>\n<tr>\n<td><strong>Exercise performance<\/strong><\/td>\n<td><strong>Improves strength performance and endurance and accelerates postexercise <\/strong><a href=\"https:\/\/pmc.ncbi.nlm.nih.gov\/articles\/PMC8885183\/#B278\" data-saferedirecturl=\"https:\/\/www.google.com\/url?q=https:\/\/pmc.ncbi.nlm.nih.gov\/articles\/PMC8885183\/%23B278&amp;source=gmail&amp;ust=1768165933933000&amp;usg=AOvVaw2sjma-2dnfC5f4HDCa13jx\"><strong>recovery<\/strong><\/a><\/td>\n<td><\/td>\n<\/tr>\n<tr>\n<td><strong>Cognitive function<\/strong><\/td>\n<td><strong>Cognitive improvement in overweight men; improves <\/strong><a href=\"https:\/\/pmc.ncbi.nlm.nih.gov\/articles\/PMC8885183\/#B279\" data-saferedirecturl=\"https:\/\/www.google.com\/url?q=https:\/\/pmc.ncbi.nlm.nih.gov\/articles\/PMC8885183\/%23B279&amp;source=gmail&amp;ust=1768165933934000&amp;usg=AOvVaw2wn4xNqKWSPH8f1zXjWqe_\"><strong>visual learning<\/strong><\/a><\/td>\n<td><\/td>\n<\/tr>\n<tr>\n<td><strong>Skin conditions<\/strong><\/td>\n<td><strong>Induce improvement in patients with hyperpigmentation and <\/strong><a href=\"https:\/\/pmc.ncbi.nlm.nih.gov\/articles\/PMC8885183\/#B280\" data-saferedirecturl=\"https:\/\/www.google.com\/url?q=https:\/\/pmc.ncbi.nlm.nih.gov\/articles\/PMC8885183\/%23B280&amp;source=gmail&amp;ust=1768165933934000&amp;usg=AOvVaw3N6TvWL_1lWDOLdaBMGZO0\"><strong>dark spots<\/strong><\/a><\/td>\n<td><\/td>\n<\/tr>\n<tr>\n<td><\/td>\n<td><strong>Patients with melasma showed significant <\/strong><a href=\"https:\/\/pmc.ncbi.nlm.nih.gov\/articles\/PMC8885183\/#B281\" data-saferedirecturl=\"https:\/\/www.google.com\/url?q=https:\/\/pmc.ncbi.nlm.nih.gov\/articles\/PMC8885183\/%23B281&amp;source=gmail&amp;ust=1768165933934000&amp;usg=AOvVaw0c6S9Z0F0X4a-kAw15b__p\"><strong>improvement<\/strong><\/a><strong> after <\/strong><a href=\"https:\/\/pmc.ncbi.nlm.nih.gov\/articles\/PMC8885183\/#B282\" data-saferedirecturl=\"https:\/\/www.google.com\/url?q=https:\/\/pmc.ncbi.nlm.nih.gov\/articles\/PMC8885183\/%23B282&amp;source=gmail&amp;ust=1768165933934000&amp;usg=AOvVaw17t5AskLG8k5f77uWPhHvS\"><strong>treatment<\/strong><\/a><\/td>\n<td><\/td>\n<\/tr>\n<tr>\n<td><\/td>\n<td><strong>Lead to increased UV damage <\/strong> <a href=\"https:\/\/pmc.ncbi.nlm.nih.gov\/articles\/PMC8885183\/#B283\" data-saferedirecturl=\"https:\/\/www.google.com\/url?q=https:\/\/pmc.ncbi.nlm.nih.gov\/articles\/PMC8885183\/%23B283&amp;source=gmail&amp;ust=1768165933934000&amp;usg=AOvVaw3OdRqVmpFDbzfcCKJquE0i\"><strong>protection<\/strong><\/a><\/td>\n<td><\/td>\n<\/tr>\n<tr>\n<td><\/td>\n<td><strong>Having antiwrinkle activity, increasing the expression of <\/strong><a href=\"https:\/\/pmc.ncbi.nlm.nih.gov\/articles\/PMC8885183\/#B284\" data-saferedirecturl=\"https:\/\/www.google.com\/url?q=https:\/\/pmc.ncbi.nlm.nih.gov\/articles\/PMC8885183\/%23B284&amp;source=gmail&amp;ust=1768165933934000&amp;usg=AOvVaw31EBJNdHuwp8RXir242Ujt\"><strong>type I collagen mRNA<\/strong><\/a><\/td>\n<td><\/td>\n<\/tr>\n<tr>\n<td><strong>Insulin resistance and diabetes<\/strong><\/td>\n<td><strong>Induce reduction in <\/strong><a href=\"https:\/\/pmc.ncbi.nlm.nih.gov\/articles\/PMC8885183\/#B285\" data-saferedirecturl=\"https:\/\/www.google.com\/url?q=https:\/\/pmc.ncbi.nlm.nih.gov\/articles\/PMC8885183\/%23B285&amp;source=gmail&amp;ust=1768165933934000&amp;usg=AOvVaw17Z5OLz36KeS_lp6BYGkDR\"><strong>blood glucose<\/strong><\/a> <a href=\"https:\/\/pmc.ncbi.nlm.nih.gov\/articles\/PMC8885183\/#B286\" data-saferedirecturl=\"https:\/\/www.google.com\/url?q=https:\/\/pmc.ncbi.nlm.nih.gov\/articles\/PMC8885183\/%23B286&amp;source=gmail&amp;ust=1768165933934000&amp;usg=AOvVaw3aXdBQME_FNB8yCBN4ccav\"><strong>levels<\/strong><\/a><\/td>\n<td><\/td>\n<\/tr>\n<tr>\n<td><strong>Cardiovascular disease risk factors<\/strong><\/td>\n<td><strong>Decrease carotid artery intima-media thickness; decrease in mean peak systolic velocity and end-diastolic velocity of <\/strong><a href=\"https:\/\/pmc.ncbi.nlm.nih.gov\/articles\/PMC8885183\/#B288\" data-saferedirecturl=\"https:\/\/www.google.com\/url?q=https:\/\/pmc.ncbi.nlm.nih.gov\/articles\/PMC8885183\/%23B288&amp;source=gmail&amp;ust=1768165933934000&amp;usg=AOvVaw1WSqad25l0whowwsO5AmSA\"><strong>carotid arteries<\/strong><\/a><\/td>\n<td><\/td>\n<\/tr>\n<tr>\n<td><\/td>\n<td><strong>Reduction in stress-induced <\/strong> <a href=\"https:\/\/pmc.ncbi.nlm.nih.gov\/articles\/PMC8885183\/#B289\" data-saferedirecturl=\"https:\/\/www.google.com\/url?q=https:\/\/pmc.ncbi.nlm.nih.gov\/articles\/PMC8885183\/%23B289&amp;source=gmail&amp;ust=1768165933934000&amp;usg=AOvVaw3pShOgvWAr72DmlDo07KeF\"><strong>ischemia<\/strong><\/a><\/td>\n<td><\/td>\n<\/tr>\n<tr>\n<td><\/td>\n<td><strong>Significant reductions in <\/strong><a href=\"https:\/\/pmc.ncbi.nlm.nih.gov\/articles\/PMC8885183\/#B290\" data-saferedirecturl=\"https:\/\/www.google.com\/url?q=https:\/\/pmc.ncbi.nlm.nih.gov\/articles\/PMC8885183\/%23B290&amp;source=gmail&amp;ust=1768165933934000&amp;usg=AOvVaw25HgMrrLJIUVuSdO9YIbhN\"><strong>systolic and diastolic<\/strong><\/a> <a href=\"https:\/\/pmc.ncbi.nlm.nih.gov\/articles\/PMC8885183\/#B291\" data-saferedirecturl=\"https:\/\/www.google.com\/url?q=https:\/\/pmc.ncbi.nlm.nih.gov\/articles\/PMC8885183\/%23B291&amp;source=gmail&amp;ust=1768165933934000&amp;usg=AOvVaw0g18erddYjzDLL5TYlC72_\"><strong>blood pressure<\/strong><\/a><\/td>\n<td><\/td>\n<\/tr>\n<tr>\n<td><\/td>\n<td><strong>No effect on plasma concentrations of <\/strong><a href=\"https:\/\/pmc.ncbi.nlm.nih.gov\/articles\/PMC8885183\/#B292\" data-saferedirecturl=\"https:\/\/www.google.com\/url?q=https:\/\/pmc.ncbi.nlm.nih.gov\/articles\/PMC8885183\/%23B292&amp;source=gmail&amp;ust=1768165933934000&amp;usg=AOvVaw0AUrwuPy9BXCQB1y1FfE2i\"><strong>cholesterol,<\/strong><\/a><strong> LDL-C, HDL-C, or <\/strong><a href=\"https:\/\/pmc.ncbi.nlm.nih.gov\/articles\/PMC8885183\/#B293\" data-saferedirecturl=\"https:\/\/www.google.com\/url?q=https:\/\/pmc.ncbi.nlm.nih.gov\/articles\/PMC8885183\/%23B293&amp;source=gmail&amp;ust=1768165933934000&amp;usg=AOvVaw2R2h0bNdTUkOKlndML_nwY\"><strong>triglycerides<\/strong><\/a><\/td>\n<td><\/td>\n<\/tr>\n<tr>\n<td><strong>Osteoarthritis<\/strong><\/td>\n<td><strong>Significant decrease in WOMAC stiffness and physical <\/strong><a href=\"https:\/\/pmc.ncbi.nlm.nih.gov\/articles\/PMC8885183\/#B294\" data-saferedirecturl=\"https:\/\/www.google.com\/url?q=https:\/\/pmc.ncbi.nlm.nih.gov\/articles\/PMC8885183\/%23B294&amp;source=gmail&amp;ust=1768165933934000&amp;usg=AOvVaw0d9gNlugHRtZgGP9pwYqwn\"><strong>function scores<\/strong><\/a><\/td>\n<td><\/td>\n<\/tr>\n<tr>\n<td><strong>Fatigue, insomnia<\/strong><\/td>\n<td><strong>Improvement in fatigue and insomnia questionnaire <\/strong><a href=\"https:\/\/pmc.ncbi.nlm.nih.gov\/articles\/PMC8885183\/#B295\" data-saferedirecturl=\"https:\/\/www.google.com\/url?q=https:\/\/pmc.ncbi.nlm.nih.gov\/articles\/PMC8885183\/%23B295&amp;source=gmail&amp;ust=1768165933934000&amp;usg=AOvVaw0Kri5JL8S6yD3ahaH4nhlA\"><strong>scores<\/strong><\/a><\/td>\n<td><\/td>\n<\/tr>\n<tr>\n<td><strong>Prostate cancer<\/strong><\/td>\n<td><strong>Ellagic acid effects as <\/strong><a href=\"https:\/\/pmc.ncbi.nlm.nih.gov\/articles\/PMC8885183\/#B296\" data-saferedirecturl=\"https:\/\/www.google.com\/url?q=https:\/\/pmc.ncbi.nlm.nih.gov\/articles\/PMC8885183\/%23B296&amp;source=gmail&amp;ust=1768165933934000&amp;usg=AOvVaw0QIyS1tlYQhq_c25OQpGB7\"><strong>adjuvant therapy<\/strong><\/a><strong> for chemotherapeutic treatment: less risk of developing neutropenia than patients receiving chemotherapy alone; PSA reduction; reduction gastrointestinal side effects<\/strong><\/td>\n<td><\/td>\n<\/tr>\n<tr>\n<td><strong>Human fertility<\/strong><\/td>\n<td><strong>Increase in total number of <\/strong> <a href=\"https:\/\/pmc.ncbi.nlm.nih.gov\/articles\/PMC8885183\/#B297\" data-saferedirecturl=\"https:\/\/www.google.com\/url?q=https:\/\/pmc.ncbi.nlm.nih.gov\/articles\/PMC8885183\/%23B297&amp;source=gmail&amp;ust=1768165933934000&amp;usg=AOvVaw2aIQ1a7qizkxfl6w5_KS0u\"><strong>motile spermatozoa<\/strong><\/a><\/td>\n<td><\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<p>&nbsp;<\/p>\n<p><strong>Registered trials have also focused on non-alcoholic fatty liver disease (NAFLD) and multiple sclerosis, using doses like 180 mg\/day of pure ellagic acid for 8 weeks, which showed cytokine modulation and improved lipid profiles.\u00a0<\/strong><\/p>\n<p><strong>More Benefits: Inhibition of the SARS-CoV-2 3CL<sup>pro<\/sup> Main Protease by Plant Polyphenol<\/strong><\/p>\n<p>Researcher <em>Miha Bahun<\/em> published a compelling article early into the COVID-19 pandemic on the abundance of polyphenols in edible plants as an inhibitory agent against an important SARS-CoV-2 therapeutic target, the protease 3CL<sup>pro<\/sup> in addition to being critical components of good human nutrition.\u00a0 The research team applied <em>in-silico<\/em> molecular docking as well as molecular dynamics supported by <em> in-vitro<\/em> assays to determine the inhibitory potential of plant polyphenols including <strong>quercetin, ellagic acid, curcumin, epigallocatechin gallate and resveratrol.<\/strong> These researchers found <strong>evidence for inhibition of SARS-CoV-2 3CL<sup>pro<\/sup> by these natural plant polyphenols with <\/strong>Ellagic acid among the strongest 3CL<sup>pro<\/sup>\u00a0inhibitor.\u00a0 That is a powerful potential benefit across many body systems.<\/p>\n<p>Unfortunately, the major long COVID trials (e.g., NCT06928272) only focus on repurposed pharmaceutical products (metformin, fluvoxamine, naltrexone, antiplatelets), and do not include polyphenols such as ellagic acid or pomegranate. I think this is a major deficiency in the research models specifically related to COVID and COVID vax injury.\u00a0 For that reason, I think the current evidence on ellagic acid illustrates that we have an opportunity to benefit from ellagic acid supplements without the side effects of Rx medicines.\u00a0 There is very little risk and potential for significant improvement in health and function.<\/p>\n<p><strong>Dietary Sources Comparisons<\/strong><\/p>\n<p><a href=\"https:\/\/www.medicinenet.com\/ellagic_acid_what_is_it_how_it_works_sources\/article.htm\" data-saferedirecturl=\"https:\/\/www.google.com\/url?q=https:\/\/www.medicinenet.com\/ellagic_acid_what_is_it_how_it_works_sources\/article.htm&amp;source=gmail&amp;ust=1768165933934000&amp;usg=AOvVaw2osn9CjK1bbBY_w1vV5c4u\">Ellagic acid<\/a> is found abundantly in fruits such as pomegranates, raspberries, strawberries, cranberries, and blackberries, as well as nuts (notably walnuts and pecans) and tree bark. In nature, it often exists as ellagitannins, which are hydrolyzed in the gastrointestinal tract to yield free ellagic acid. The <em>bioavailability of ellagic acid is limited by its poor solubility and rapid metabolism, <\/em>but regular dietary intake through ellagitannin-rich foods approach or a stabilized high-quality supplement, like our <strong><a href=\"https:\/\/shoptruthforhealth.com\/products\/trufruits-berries?variant=46473613967682\">TruFruits &amp; Berries\u2122<\/a><a href=\"https:\/\/shoptruthforhealth.com\/collections\/supplements\/products\/trufruits-berries\" data-saferedirecturl=\"https:\/\/www.google.com\/url?q=https:\/\/shoptruthforhealth.com\/collections\/supplements\/products\/trufruits-berries&amp;source=gmail&amp;ust=1768165933935000&amp;usg=AOvVaw2DTanghXji-9PZKVpVO90S\">,<\/a><\/strong> are two approaches to increase systemic levels.<\/p>\n<p><strong>Highest Ellagic Acid Concentration Sources: Pomegranate and Berries<\/strong><\/p>\n<p>Pomegranates are the top powerhouse for ellagic acid, especially juice at 811 mg\/L, with berries the next most concentrated sources of ellagic acid.\u00a0 In the berry category, Cloudberries are the highest at 315 mg\/100g, then wild strawberries have up to 10 times more ellagic acid than cultivated varieties, followed by raspberries (around 270 mg\/100g fresh weight), blackberries, cranberries, Muscadine grapes and boysenberries.<\/p>\n<p><strong>Comparing Pomegranate Sources of Ellagic Acid<\/strong><\/p>\n<p>Pomegranate <strong>juice typically contains more ellagic acid than the edible arils (seeds and juice sacs) of the whole fruit,\u00a0 <\/strong><em>primarily because processing methods for the juice incorporate components from the antioxidant-rich pomegranate peel<\/em>.<\/p>\n<ul>\n<li>Pure pomegranate juice averages 2-17 mg\/100 ml of ellagic acid, with concentrate reaching higher (17.28 mg\/100 ml).<\/li>\n<li>Cold-pressed or whole-fruit juice can deliver higher concentrations (e.g., up to 121 mg\/L ellagic acid or 811 mg\/L from precursors) compared to the edible arils alone, which have lower free ellagic acid levels.<\/li>\n<li>Standard commercial juices vary, but those from whole fruit outperform aril-only extracts. For optimal benefit, select cold-pressed juices over clarified varieties to enhance bioavailability.<\/li>\n<li>The whole fruit arils provide less due to minimal peel inclusion\u2014peel holds most ellagitannins like punicalagin (11-20 g\/kg) that hydrolyze to ellagic acid.<\/li>\n<\/ul>\n<p><strong>Nuts and Fruits<\/strong><\/p>\n<p>Walnuts contain about 59 mg\/100g, pecans around 33 mg\/100g.\u00a0 Chestnuts, grapes, and peaches provide smaller but relevant quantities. For optimal intake, prioritize fresh or minimally processed sources of ellagic acid like berries and nuts.<\/p>\n<p><strong><a href=\"https:\/\/shoptruthforhealth.com\/products\/trufruits-berries?variant=46473613967682\">TruFruits &amp; Berries\u2122<\/a>: Optimal Bio-availability Plus\u00a0 Convenience! <\/strong><\/p>\n<p><strong>Truth for Health\u2019s TruFruits &amp; Berries\u2122 <\/strong>is a proprietary supplement featuring a blend of polyphenol-rich fruit and berry extracts, with <strong>pomegranate (Punica granatum) whole fruit extract as the primary source of ellagitannins.\u00a0 Ellagitannins,<\/strong> particularly punicalagin, are the optimal form efficiently hydrolyzed in the gut to yield ellagic acid and bioactive metabolites (urolithins). Other ingredients\u2014cranberry, grape, blueberry, chokeberry, mangosteen, apple, and bilberry\u2014contribute additional polyphenols, but it is the pomegranate and, to a lesser degree, cranberry that provide significant ellagitannin content.<\/p>\n<p><strong><a href=\"https:\/\/shoptruthforhealth.com\/products\/trufruits-berries?variant=46473613967682\">TruFruits &amp; Berries\u2122<\/a> <\/strong><strong>Estimated Ellagitannin by Ingredient<\/strong><\/p>\n<table>\n<tbody>\n<tr>\n<td><strong>Ingredient<\/strong><\/td>\n<td><strong>Typical Ellagitannin Level (per 100g extract)<\/strong><\/td>\n<td><strong>Notes <\/strong><\/td>\n<\/tr>\n<tr>\n<td>Pomegranate (whole fruit)<\/td>\n<td>1,000\u201320,000 mg (punicalagins dominant)<\/td>\n<td>Highest; peel-inclusive extracts yield most<\/td>\n<\/tr>\n<tr>\n<td>Cranberry (whole berry)<\/td>\n<td>70\u2013110 mg<\/td>\n<td>Moderate from berries<\/td>\n<\/tr>\n<tr>\n<td>Blueberry (whole berry)<\/td>\n<td>50\u2013100 mg<\/td>\n<td>Low-moderate<\/td>\n<\/tr>\n<tr>\n<td>Chokeberry (whole berry)<\/td>\n<td>40\u201380 mg<\/td>\n<td>Primarily other polyphenols<\/td>\n<\/tr>\n<tr>\n<td>Bilberry (whole berry)<\/td>\n<td>30\u201370 mg<\/td>\n<td>Minor contribution<\/td>\n<\/tr>\n<tr>\n<td>Grape (seed\/skin\/pulp)<\/td>\n<td>&lt;20 mg<\/td>\n<td>Negligible; proanthocyanidins main<\/td>\n<\/tr>\n<tr>\n<td>Mangosteen (skin)<\/td>\n<td>10\u201350 mg<\/td>\n<td>Low<\/td>\n<\/tr>\n<tr>\n<td>Apple (skin)<\/td>\n<td>&lt;10 mg<\/td>\n<td>Trace<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<p>&nbsp;<\/p>\n<p><strong>Pomegranate stands out as the dominant ellagitannin source in <a href=\"https:\/\/shoptruthforhealth.com\/products\/trufruits-berries?variant=46473613967682\">TruFruits &amp; Berries,<\/a><\/strong><a href=\"https:\/\/shoptruthforhealth.com\/products\/trufruits-berries?variant=46473613967682\"><strong>\u2122<\/strong><\/a><strong> with content far exceeding cranberry and other fruits.<\/strong> This fits with prior studies showing pomegranate is superior for ellagic acid precursors in whole fruit formulations.<\/p>\n<p>A typical <strong><a href=\"https:\/\/shoptruthforhealth.com\/products\/trufruits-berries?variant=46473613967682\">TruFruits &amp; Berries\u2122<\/a>\u00a0<\/strong>dosage is <strong>1 capsule (500 mg blend) twice daily<\/strong>, which is consistent with with dosages used in human studies of pure ellagic acid for cytokine modulation and antioxidant effects.<\/p>\n<p>Ellagitannins are precursors that can release ellagic acid (EA), but the conversion is incomplete since it is influenced by gut microorganism balance, and is also dependent on matrix- and structure of the source, so there is no fixed, reliable \u201cmg ellagitannin = mg pure EA\u201d dosing equivalence. Therefore, labels cannot guarantee translation of ellagitannins into equivalent systemic Ellagic Acid or urolithin exposure for different individuals.<\/p>\n<p><strong>In Summary:<\/strong><\/p>\n<p>Ellagic acid is a structurally unique polyphenol with significant antioxidant and anti-inflammatory properties, that primarily comes from pomegranate, berries, and nuts. Preclinical studies of its activity support many potential health benefits relevant to long COVID, COVID vaccine injury, amyloid clots, and cardiomyopathy.\u00a0 The antioxidant and anti-inflammatory properties mainly occur through modulation of reactive oxygen species (ROS), cytokines, and pathways that cause fibrosis.\u00a0 Further research is needed to quantify more specifically ellagic acid\u2019s role in amyloid microclot reduction, long COVID and vaccine injury efficacy, since there are wide variations in individual absorption and utilization.<\/p>\n<p>I remain optimistic, based on the scientific and other clinical data we do have, that these natural treatments for long COVID and post-COVID vaccine injuries have significant enough benefits on the pathways involved in the damage that it makes sense to use them, since side effects are minimal to non-existent \u2013unlike most prescription pharmaceutical products being used in clinical trials.\u00a0 I take our <strong><a href=\"https:\/\/shoptruthforhealth.com\/products\/trufruits-berries?variant=46473613967682\">TruFruits &amp; Berries\u2122<\/a> <\/strong>and recommend it to my patients as part of my core \u201cHealth and Resilience\u201d crucial supplements for general antioxidant support, anti-inflammatory and promising anti-viral and anti-thrombotic effects.\u00a0 There is little to lose and much to gain!\u00a0 For balance, I also include high-quality dietary sources in my own meal plans and recommend those for my patients as well.<\/p>\n<p><strong>Additional resources:<\/strong><br \/>\n<a href=\"https:\/\/cdn.shopify.com\/s\/files\/1\/0796\/4065\/8242\/files\/TruFruits_Berries.pdf?v=1698794264\" data-saferedirecturl=\"https:\/\/www.google.com\/url?q=https:\/\/cdn.shopify.com\/s\/files\/1\/0796\/4065\/8242\/files\/TruFruits_Berries.pdf?v%3D1698794264&amp;source=gmail&amp;ust=1768165933936000&amp;usg=AOvVaw3oVo7dAPsswuXCIWWhes-B\">TruFruits &amp; Berries\u2122Product Data Sheet<\/a><br \/>\n<a href=\"https:\/\/www.truthforhealth.org\/es\/2025\/06\/fruit-and-vegetable-intake-have-a-well-recognized-correlation-with-health\/\" data-saferedirecturl=\"https:\/\/www.google.com\/url?q=https:\/\/www.truthforhealth.org\/2025\/06\/fruit-and-vegetable-intake-have-a-well-recognized-correlation-with-health\/&amp;source=gmail&amp;ust=1768165933936000&amp;usg=AOvVaw0es7V3zuxV5pMvTgHVyAUl\">Fruits and Berries Intake Have a Well-Recognized Correlation with Health<\/a><\/p>\n<p><strong>CAUTION: <\/strong>As always, we urge you to avoid supplements without checking knowledgeable sources to evaluate your medical situation, proper lab tests to verify what is needed, and to make sure to avoid adverse interactions with prescription medicines and other supplements you take.<\/p>\n<p>All Truth for Health Foundation Products Meet or Exceed cGMP Quality Standards, the highest quality standard for supplements sold in the USA.\u00a0 <strong><em>For more information, references from studies are listed in the Product Data Sheets for each product, available on our website.<\/em><\/strong>\u00a0 Under medical practice regulations, we are unable to answer individual medical questions or make specific individual supplement recommendations for people who are not established patients of Dr. Vliet\u2019s independent medical practice.<\/p>\n<p><strong>I encourage you to consider our other natural medicines with our top quality, cGMP-compliant professional formulas: TruMitochondrial\u2122 Boost,\u00a0 TruNAC\u2122, Tru BioD3, Tru B Complex Full Spectrum, TruZinc\u2122, TruC with BioFlav\u2122 (Vitamin C with complete Bioflavonoids), TruImmune\u2122 Boost, <a href=\"https:\/\/shoptruthforhealth.com\/collections\/supplements\/products\/truimmunoglobulin\" data-saferedirecturl=\"https:\/\/www.google.com\/url?q=https:\/\/shoptruthforhealth.com\/collections\/supplements\/products\/truimmunoglobulin&amp;source=gmail&amp;ust=1768165933936000&amp;usg=AOvVaw1bSNXBUhlurjFVJFhjqc2C\">TruImmunoglobulin\u2122<\/a>, and TruProBiotic\u2122 Daily to replenish critical bifidobacteria depleted by COVID shots, viral illnesses, and antibiotic therapy.<\/strong><\/p>\n<p><strong>To Your good health and improving resilience!<\/strong><br \/>\n<strong>Elizabeth Lee Vliet, MD<\/strong><\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<table width=\"100%\">\n<tbody>\n<tr>\n<td>\n<table width=\"100%\">\n<tbody>\n<tr>\n<td><a href=\"https:\/\/www.truthforhealth.org\/es\/category\/health-tips\/\"><u><strong>C<\/strong><em><strong>lick here to read Dr. Vliet\u2019s Health Tips<br \/>\non these and more products. <\/strong><\/em><\/u><\/a><\/p>\n<p><strong>Visit Truth for Health Store! <\/strong><br \/>\n<strong>Welcome to <em>Little Pharma\u2122<\/em><\/strong><\/p>\n<p><strong><a href=\"http:\/\/www.TruthforHealth.org\" data-saferedirecturl=\"https:\/\/www.google.com\/url?q=http:\/\/www.TruthforHealth.org&amp;source=gmail&amp;ust=1734366877562000&amp;usg=AOvVaw0cxk5Z-BcOO9htxgYwFum2\">www.TruthforHealth.org<\/a> OR <a href=\"http:\/\/www.ShopTruthforHealth.com\" data-saferedirecturl=\"https:\/\/www.google.com\/url?q=http:\/\/www.ShopTruthforHealth.com&amp;source=gmail&amp;ust=1734366877562000&amp;usg=AOvVaw3hJwfpUhJ61YBQG2Pm2nPR\">www.ShopTruthforHealth.com<\/a><\/strong><\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<\/td>\n<\/tr>\n<\/tbody>\n<\/table>","protected":false},"excerpt":{"rendered":"<p>\u00a9 by Elizabeth Lee Vliet MD and Kathy Kresnik \u201cLong COVID\u201d and debilitating damage from COVID \u201cvaccines\u201d plaque millions of people around the world, creating complex clinical challenges for medical &hellip; <\/p>","protected":false},"author":21,"featured_media":10525,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":""},"categories":[222],"tags":[],"class_list":["post-10524","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-health-tips","fadeIn","image-hover-transition-effect","latest_post"],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v28.5 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>Dr. Vliet\u2019s Health Tip:From Pomegranate Power to Cardiac Amyloid Clearance: Ellagic Acid&#039;s Breakthrough for \u201cLong COVID\u201d, Vax Injury &amp; Deadly Heart Deposits - Truth for Health Foundation<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.truthforhealth.org\/es\/2026\/01\/dr-vliets-health-tipfrom-pomegranate-power-to-cardiac-amyloid-clearance-ellagic-acids-breakthrough-for-long-covid-vax-injury-deadly-heart-deposits\/\" \/>\n<meta property=\"og:locale\" content=\"es_MX\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Dr. Vliet\u2019s Health Tip:From Pomegranate Power to Cardiac Amyloid Clearance: Ellagic Acid&#039;s Breakthrough for \u201cLong COVID\u201d, Vax Injury &amp; 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