{"id":10268,"date":"2025-09-03T14:45:34","date_gmt":"2025-09-03T14:45:34","guid":{"rendered":"https:\/\/www.truthforhealth.org\/?p=10268"},"modified":"2025-09-03T14:49:26","modified_gmt":"2025-09-03T14:49:26","slug":"covid-triggers-of-amyloid-fibrin-clots-aggravating-fibromyalgia-muscle-joint-pain","status":"publish","type":"post","link":"https:\/\/www.truthforhealth.org\/es\/2025\/09\/covid-triggers-of-amyloid-fibrin-clots-aggravating-fibromyalgia-muscle-joint-pain\/","title":{"rendered":"COVID Triggers of Amyloid & Fibrin Clots Aggravating Fibromyalgia, Muscle & Joint Pain"},"content":{"rendered":"

\u00a9 by Elizabeth Lee Vliet MD and Kathy Kresnik<\/em><\/span><\/span><\/p>\n

I have spent many years working with fibromyalgia (FMS) and musculoskeletal pain patients trying to unravel the tangled thread of the many factors that contribute to these pain syndromes.\u00a0 They don\u2019t respond well to just one or two medicines \u2013 it has always involved multiple therapeutic modalities, as we have been exploring in this series on the broad problem of fibromyalgia and other pain syndromes, but it is even more complicated today with the added damage from the COVID shots that most doctors are still ignoring<\/em>, just as they have ignored the hormone imbalances triggering pain over my whole career!<\/p>\n

Today I want to address two more overlooked crucial sources of damage\u2014the abnormal \u201cwhite clots\u201d we now know are amyloid-based clots, and the more widely appreciated micro blood clot\u2014both of which have led to the dramatic rise in fibromyalgia and other pain syndromes since the experimental COVID shots were rolled out in 2021. While the media isn\u2019t talking about it, and most doctors ignore these findings, a few cardiologists and embalmers from many countries have been speaking out about these unusual massive, white, rubbery clots causing major and widespread vascular obstructions throughout the body.<\/p>\n

In a recent post<\/a> \u201cBloodstream Code Red: The Amyloid Clots in COVID\u2019s Wake That Nobody\u2019s Discussing\u201d,<\/em> Dr. Philip McMillan discusses the discovery of misfolded proteins, called amyloid, accumulating at the injection sites of COVID-19 vaccinated. As he puts it, \u201cthis wasn\u2019t supposed to happen\u2026suggesting something entirely new was occurring\u201d<\/em>. We have known since the 1970-1980 time frame that amyloid plaques can form in the brain, heart, lungs, kidneys in particular but since the COVID shots were unleashed on people, we have now learned that the spike protein appears to be causing the same protein misfolding that causes the devasting condition of amyloid damage to critical organs, leading to what Dr. McMillan has called the \u201cemergence of a potentially new form of systemic disease.\u201d<\/p>\n

What exactly is amyloid, and condition amyloidosis <\/em>it causes?<\/strong>
\nI have written on this extensively in an earlier health tip (see What Is Amyloidosis?<\/a>) and we have done several seminars on this condition as an outgrowth of COVID shot damage.\u00a0 See Faith Over Fear Archive on our website.\u00a0 Amyloids are aggregates of proteins characterized by a fibrillar morphology, typically measuring 7\u201313 nanometers in diameter. Amyloids result from the misfolding and aggregation of proteins and can accumulate in any organ or tissue. The buildup may happen in a single organ (localized) or throughout the body (systemically). This buildup disrupts normal functioning and can make the organs not work properly.<\/p>\n

Amyloid abnormal proteins play a significant role in heart, brain and lung damage following both the COVID illness and the COVID injections, as well as the rise in \u201cturbo cancers\u201d, and a variety of chronic medical conditions\u2013dementia, neurodegenerative disorders, heart and kidney failure for example.<\/p>\n

Multi-organ damage due to amyloid deposits is a very active area of research in medicine and biology. In 2022, researchers discovered a link between harmful amyloid production and COVID-19 symptoms. In patients with serious and long-term COVID-19,\u00a0researchers<\/a>\u00a0have discovered that the body\u2019s immune system can affect the spike protein on the surface of the SARS-CoV-2 virus,\u00a0leading to the production of a misfolded spike protein called amyloid.<\/a><\/p>\n

Amyloidosis<\/em> is a group of less common medical syndromes caused by the accumulation of these clumps of misfolded proteins.\u00a0It can affect various organs, including the heart, kidneys, liver, spleen, nervous system, and digestive tract34<\/sup>.<\/a>\u00a0Depending on the affected organ, amyloidosis can lead to symptoms such as heart failure, kidney dysfunction, lung damage, cognitive decline, dementia, neuropathy (nerve damage), and skin changes.\u00a0 There are many different types of\u00a0amyloidosis.<\/a>\u00a0Some are hereditary and some are secondary to other medical conditions, such as inflammatory conditions (obesity, diabetes, metabolic syndrome, infections, autoimmune disorders, and others) or long-term dialysis.<\/p>\n

We know now that these amyloid-based or \u201cwhite\u201d clots,<\/em> as well as the more common fibrin-based micro blood clots, block arteries and small blood vessels leading to silent hypoxia and organ dysfunction even without obvious thrombosis (macro-clots). When venous return is affected reactive oxygen species (ROS) and lactic acid build up causing muscle pain and exacerbates fibromyalgia symptoms. Adequate circulation is essential to deliver oxygen and nutrients and remove waste products to keep pain syndromes under control, just as I discussed in my previous health tip<\/a>: Vascular & Lymphatic Damage: The Painful Connection in Fibromyalgia & COVID-19 .\u00a0\u00a0 <\/em>Now that we know what these abnormal white (amyloid) clots AND micro blood clots can damage all these tissues and pathways, we see the many ways that these clots can contribute to worsening FMS pain.<\/p>\n

There is also a subset of amyloid proteins called \u201cprions.\u201d Prion diseases are a group of fatal neurodegenerative disorders caused by the accumulation of misfolded proteins in the brain. Prions, short for “proteinaceous infectious particles,”<\/em> are resistant to our usual methods of break-down, and can cause widespread tissue damage.<\/p>\n

Now here is the connection that led me into wanting to discuss this \u201cpain link.\u201d Retired organic chemist Greg Harrison and embalmer Richard Hirschman sent samples of the white fibrous clots to Dr. Kevin McCairn to request that he check these white clots for the presence of prions<\/em>. Dr. McCairn is a distinguished neuroscientist who has spent his career studying the effects of amyloid proteins on patients suffering from Alzheimer\u2019s, Parkinson\u2019s disease, and dementia.<\/p>\n

Dr. McCairn performed\u00a0Raman spectroscopy<\/strong>\u00a0which demonstrated clear signature peaks consistent with \u03b2-sheet-rich amyloid fibrils, particularly in the amide I and III regions (typically around ~1,660\u20131,670 cm\u207b\u00b9 and ~1,240\u20131,300 cm\u207b\u00b9, respectively). This confirmed the results of the prior Congo Red and Thioflavin-T tests performed on the clots.\u00a0 Then, in March 2025, Dr. McCairn performed a\u00a0Real-Time Quaking-Induced Conversion Test<\/strong>\u00a0(i.e., \u201cRT-QuIC Test\u201d)<\/strong>\u00a0on 3 different white fibrous clot samples to determine the presence of prion-like seeding activity.<\/p>\n

The stunning finding was that all 3 samples of these white clots tested \u201cpositive\u201d for prion-like seeding activity.<\/strong> Dr. McCairn\u2019s work strongly suggests the misfolded proteins (prions) triggered by SARS-CoV-2 spike protein creates system-wide damage that resists the body\u2019s natural clearing mechanisms.\u00a0 McCairn identified a crucial difference with spike-induced amyloidosis (as compared to cellar confined amyloids) that makes it far more dangerous. \u201cThe boundary condition for these amyloidogenic micro clots is essentially the system,\u201d allowing them to expand throughout the entire circulatory system,<\/em> potentially reaching the massive sizes now being discovered.\u00a0 This is unlike anything we have seen before!<\/p>\n

In addition, our body\u2019s fibrinogen no longer acts normally to convert to fibrin in healthy clot formation, but appears to misfold into an amyloid-like structure that resists the body\u2019s natural clot-dissolving mechanisms and also acts with prion-like behavior.\u00a0 This is a very ominous finding, and again unlike any damage we have seen before in my medical career.
\nThese abnormal, misfolded proteins, or prions, and the abnormal function of fibrinogen, add yet more links to the many causes of COVID-shot induced worsening pain syndromes because of widespread damage to muscle tissues, nerves and vascular\/lymphatic pathways.<\/p>\n

As I said earlier in this series, there are many mechanisms underlying the diffuse pain in FMS and other chronic pain syndromes.\u00a0 Remember all these multiple causes of damage: nerve pathways, muscle tissue itself, vascular and lymphatic vessels, connective tissue, and the endocrine-metabolic-nutritional-and oxidative pathways to provide the \u201cfuel\u201d that runs our body tissues, including muscles and nerves.<\/p>\n

Because there are so many different causes of damage, that\u2019s why it simply never works to fully resolve FMS and chronic pain with just one or two Rx medicines. We HAVE to address all of these adverse impacts on healthy nerve and muscle function.\u00a0 That is why I have been taking time to write this in-depth series on the many dimensions of FMS and chronic pain treatment that have to be addressed.<\/p>\n

The problem for most people is that we don\u2019t have many options for diagnosis or treatment, except for some innovative combination approaches I have been using that do seem to be helping.<\/p>\n

The Diagnostic Challenge: <\/strong>
\nUnfortunately, standard medical practices and facilities do not have imaging equipment to detect these micro-clots and there is limited desire to do so. There are specialty imaging protocols for MRI and CT that can help identify micro clots and amyloid deposits in heart, lungs, and brain but these have to be ordered with specialized procedures and contrast materials.\u00a0 I have included the descriptions of these specialty imaging tests in our COVID Vaccine Injury Treatment Guide<\/a>, available on our website. PET scans may detect these but are expensive and are not for routine screenings.<\/p>\n

The standard D-dimer and other coagulation markers are good initial screening for the presence of micro blood clots but may not always detect these amyloid deposits. Few laboratories offer the specialized blood analysis that Dr. McCairn has developed to identify amyloid burden, so unfortunately most physicians in medical practice do not have adequate diagnostic tools for this amyloid complication of the COVID shots.<\/p>\n

The Treatment Challenge: <\/strong>
\nStandard antiplatelet and anticoagulant medications are inadequate for resistant amyloid-based clotting disorders, so that is the reason I have been using a different approach to address the problems of mixed amyloid-fibrin clots:<\/em><\/strong>\u00a0 (1 )The prescription medicine doxycycline and (2) the natural anti-fibrinolytic medicine <\/em><\/strong>nattokinase<\/em><\/strong><\/a>, using <\/em><\/strong>TruNatto\u2122 Nattokinase<\/strong><\/a>,<\/em><\/strong> derived from fermenting soybeans.<\/em><\/strong><\/p>\n

A word of caution<\/strong>: I have seen over the years too many adverse complications of fixed-dose combination products with similar mechanisms of action, so I don\u2019t recommend buying combination products to treat these complicated problems on your own.\u00a0 For example, there are over 18 different supplements in widespread use that ALL have either anti-coagulant, or anti-platelet activity or both<\/em><\/strong>, leading to serious bleeding risks when they are used together.\u00a0 A few examples include bromelain, curcumin (turmeric), fish oils, vitamin E and many others.<\/p>\n

To address these abnormal fibrin-amyloid clots, I take the approach of using a single natural medicine, and a single RX medicine, each dosed separately for patients after a careful evaluation of laboratory studies, imaging studies when needed, and assessment of the possible interactions with other Rx medicines and natural medicine supplements.<\/p>\n

Why This 1-2 Punch Combination Works:<\/strong>
\n1-Doxycycline<\/strong> has been used for decades as an antibiotic for many bacterial illnesses.\u00a0 In fact, it was a staple medicine I always carried on scuba diving trips because it could be used for so many different types of illness and did not have many side effects, especially those that could mimic decompression illness (DCI).\u00a0 In recent years, doxycycline has been found to have much broader therapeutic effects: it works as an antiviral and I used it as part of my early home treatment for COVID, it has anti-inflammatory actions, and recent studies have shown it also interferes with the progression of amyloid plaque, and shows promising results in cardiac amyloidosis. In addition, doxycycline is also typically effective against mycoplasma, an atypical bacterium that is often part of a mixed respiratory illness mistakenly thought to be just \u201cCOVID.\u201d\u00a0 More than 80% of mycoplasma organisms are resistant to azithromycin, so doxycycline has been an important avenue for treatment.<\/p>\n

Doxycycline appears to help reduce amyloidogenic clotting in specific types of amyloidosis, particularly AL (light chain) amyloidosis with cardiac involvement, by interfering with amyloid fibril formation and promoting disruption and breakdown of amyloid plaque deposits that damage tissues. Doxycycline inhibits matrix metalloproteinases (MMPs), which are linked to amyloid-induced toxicity and tissue remodeling in amyloid diseases. Doxycycline also has been shown in animal and in vitro studies to reduce light chain cardiotoxicity by reducing amyloid load and countering the toxicity of amyloidogenic proteins in heart and other tissues.\u00a0 Here is one study that led me to add this medicine for patient with COVID-induced cardiac amyloidosis when the standard cardiology treatments were not showing results: Encouraging impact of doxycycline on early mortality in cardiac light chain (AL) amyloidosis<\/em><\/strong><\/a>.<\/em><\/strong>\u00a0 In my experience, Doxycycline is generally well tolerated when used at standard antibiotic doses and offers a safe option when few others exist to treat amyloid.<\/p>\n

2-Nattokinase<\/strong> shows potential to help treat amyloidogenic clotting by directly degrading amyloid fibrils and enhancing fibrinolytic activity according to laboratory and animal studies since we do not yet have its use human trials. Nattokinase, an enzyme extracted from fermented soybeans, exhibits strong fibrinolytic (clot-dissolving) activity at body temperature and neutral pH. It breaks down fibrin (the main structural protein in clots) and amyloid fibrils, which are implicated in both vascular and neurodegenerative diseases. It lowers blood viscosity, decreases fibrinogen levels, and enhances the body\u2019s own production of plasmin and urokinase (key enzymes in clot breakdown). Nattokinase also inactivates plasminogen activator inhibitor-1 (PAI-1), further increasing fibrinolysis.
\nAnimal research (especially in Alzheimer\u2019s models) shows vermindering of amyloid plaques and improvement in symptoms, suggesting a dual anti-clotting and anti-amyloid effect.<\/p>\n

A note of caution though:<\/strong> Due to the significant effect Nattokinase has on clot breakdown, it is important not to combine with other anticoagulants or anti-platelet medicines or supplements because it can increase the risk of serious bleeding.<\/em><\/p>\n

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Why I Use and Recommend <\/strong>TruNatto\u2122 Nattokinase<\/strong><\/a>\u00a0 in my medical practice:<\/h3>\n

TruNatto\u2122 Nattokinase<\/strong><\/a> is the natural, potent enzyme that is extracted from\u00a0natto, a fermented soybean food<\/em>\u00a0that has been consumed in Japan for over 1000 years. \u00a0TruNatto\u2122 <\/strong>Nattokinase<\/strong>\u00a0<\/a>is highly purified and our product is a unique formulation designed to escape the action of digestive enzymes so that it is optimally absorbed from the small intestine. TruNatto\u2122 <\/strong>\u00a0works to support healthy levels of fibrin and healthy blood flow through the blood vessels of our body via\u00a0protease enzyme action<\/a>\u00a0(e.g., subtilisin in protease, bacillopeptidase F) and causes the release of substances that trigger the body\u2019s production of other important enzymes that help regulate\u00a0fibrin formation<\/a>. Studies have also found that nattokinase helps to break down fibrin in blood clots, which means it has a complementary action to the anti-platelet aggregation effects of aspirin \u2013 but using them together should be done with your doctor\u2019s supervise to avoid risk of excessive bleeding with too much anti-clotting activity.<\/p>\n

TruNatto\u2122 <\/strong>also inhibits a\u00a0key enzyme<\/a>\u00a0that affects extracellular and arterial vasoconstriction, decrease red blood cell aggregation and low-shear viscosity, which is another way that nattokinase may be helpful in preventing blood clots.\u00a0 TruNatto\u2122 Nattokinase provides 1000 Fibrin units (FU) per capsule. Your health practitioner can tailor the dose to your needs. Typical dose is one to two capsules twice daily at least 30 minutes before or two hours after a meal.<\/p>\n

Background<\/strong>: Nattokinase has been used as supplement for\u00a0cardiovascular conditions<\/a>\u00a0in Japan for many years due to its atherosclerotic and antithrombotic properties. It is made through the fermentation of boiled soybeans by the bacterium Bacillus subtilis<\/em>. While other soy foods contain enzymes, it is only the natto preparation that is\u00a0fermented<\/em>\u00a0soybeans that contains the nattokinase enzyme. NOTE: Unfermented, boiled soybeans, which is the source of most soy in the American diet,\u00a0do not contain natto.\u00a0\u00a0 <\/em><\/strong>WebMD<\/a>\u00a0summarizes the health benefits of nattokinase, \u201cHigh natto consumption has been linked to the Japanese population\u2019s longer average lifespans and lower chronic disease rates. Studies show that people with diets rich in natto have lower rates of death from heart diseases.\u201d Other benefits listed include:<\/p>\n